Document Detail


Ursodeoxycholic acid for treatment of cholestasis in patients with hepatic amyloidosis.
MedLine Citation:
PMID:  19583148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Amyloidosis represents a group of different diseases characterized by extracellular accumulation of pathologic fibrillar proteins in various tissues and organs. Severe amyloid deposition in the liver parenchyma has extrahepatic involvement predominantly in the kidney or heart. We evaluated the effect of ursodeoxycholic acid, in four patients with severe hepatic amyloidosis of different etiologies, who presented with increased alkaline phosphatase and gamma-glutamyl transferase. CASE REPORT: The study included four patients who presented with amyloidosis-associated intrahepatic cholestasis. Three of them had renal amyloidosis which developed 1-3 years before cholestasis occurred, the remaining one having intrahepatic cholestasis as the primary sign of the disease. Amyloidosis was identified from liver biopsies in all patients by its specific binding to Congo red and green birefringence in polarized light. The biochemical nature and the class of amyloid deposits were identified immunohistochemically. In addition to their regular treatment, the patients received 750 mg ursodeoxycholic acid per day. After 2-4 weeks all patients had a significant decrease of serum alkaline phosphatase and gamma-glutamyl transferase, and their general status significantly improved. CONCLUSION: Treatment with ursodeoxycholic acid may be beneficial in patients with hepatic amyloidosis, and do extend indications for the use of ursodeoxycholic acid in amyloidotic cholestatic liver disease.
Authors:
Dominik Faust; Bora Akoglu; Gordana Ristic; Vladan Milovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vojnosanitetski pregled. Military-medical and pharmaceutical review     Volume:  66     ISSN:  0042-8450     ISO Abbreviation:  Vojnosanit Pregl     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21530700R     Medline TA:  Vojnosanit Pregl     Country:  Serbia    
Other Details:
Languages:  eng     Pagination:  482-6     Citation Subset:  IM    
Affiliation:
Asklepios Hospital, Department of Medicine, Langen, Germany. innere2.longen@asklepios.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amyloidosis / complications*
Cholagogues and Choleretics / therapeutic use*
Cholestasis / drug therapy*,  etiology
Female
Humans
Liver Diseases / complications*
Male
Middle Aged
Ursodeoxycholic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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