Document Detail

Ursodeoxycholic acid therapy in the treatment of biliary atresia.
MedLine Citation:
PMID:  2730950     Owner:  NLM     Status:  MEDLINE    
The prognosis of operated biliary atresia in the cases with bile excretion chiefly depends upon the prevention of ascending cholangitis. An antibiotic is therefore intravenously administered during the early postoperative phase, but cannot be used over a long period. In the cases showing satisfactory bile excretion after operation, ascending cholangitis is rare because of rapid disappearance of jaundice. Regarding this, the authors prescribed ursodeoxycholic acid (UDCA) at 10-15 mg/kg/day to 6 infants with biliary atresia for several weeks after operation, and then determined the effects of UDCA in improving jaundice and bile excretion. As a result, serum bilirubin and serum total bile acid (STBA) levels were decreased in 4 of the 6 infants. In the remaining 2 infants, their STBA levels showed no decrease, but were rather increased; these infants subsequently died of hepatic failure. These results suggested that UDCA is useful in the treatment of cholestasis associated with biliary atresia in the cases attaining postoperative bile excretion. It was also suggested that the treatment with UDCA should be stopped when the STBA levels increased after the beginning of the treatment. Therefore, it was thought that STBA levels measured during UDCA therapy could serve as a good indicator of the choleretic effect of UDCA.
H Nittono; A Tokita; M Hayashi; T Watanabe; K Obinata; N Nakatsu; T Miyano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  43     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-25     Completed Date:  1989-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / metabolism
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Biliary Atresia / drug therapy*
Bilirubin / blood
Birth Weight
Deoxycholic Acid / analogs & derivatives*
Gestational Age
Infant, Newborn
Ursodeoxycholic Acid / therapeutic use*
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid; 635-65-4/Bilirubin; 83-44-3/Deoxycholic Acid; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome.
Next Document:  An improvement of Barter's method for assaying plasma cholesterol ester transfer activity: experimen...