Document Detail


Ursodeoxycholic acid in primary biliary cirrhosis.
MedLine Citation:
PMID:  9170199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with primary biliary cirrhosis (PBC), ursodeoxycholic acid (ursodiol) improves laboratory test markers of cholestasis and hepatic inflammation as well as some hepatic histological features; it also delays histological progression in the early stages of PBC. Ursodiol is well tolerated and safe. Less well substantiated are that ursodiol either improves the quality of life or prevents liver transplantation or that it prolongs survival without transplantation. There are favorable trends for ursodiol in preventing transplantation and prolonging survival, but in the absence of randomized, placebo-controlled trials of sufficient duration, there remain impressions rather than statistically proved, strong conclusions.
Authors:
B Combes
Related Documents :
1115679 - Metaplastic cartilage in nondysplastic kidneys.
12170029 - Duct-to-duct biliary reconstruction in living donor liver transplantation utilizing rig...
9742489 - Liver transplantation for primary biliary cirrhosis and primary sclerosing cholangitis:...
19876939 - Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrh...
6363259 - The cambridge and king's college hospital experience of liver transplantation, 1968-1983.
9724479 - An open-label study of the safety and tolerability of converting stable liver transplan...
22321479 - Percutaneous mechanical thrombectomy for extensive acute lower-extremity deep venous th...
12662299 - No impact of cross-reactive group human leucocyte antigen class i matching on long-term...
18827749 - Low-dose dexamethasone-supplemented fluid resuscitation reverses endotoxin-induced acut...
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Seminars in liver disease     Volume:  17     ISSN:  0272-8087     ISO Abbreviation:  Semin. Liver Dis.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110297     Medline TA:  Semin Liver Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cholagogues and Choleretics / therapeutic use*
Female
Humans
Liver Cirrhosis, Biliary / drug therapy*
Liver Transplantation
Male
Middle Aged
Quality of Life
Randomized Controlled Trials as Topic
Survival Analysis
Ursodeoxycholic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cytokines in primary biliary cirrhosis.
Next Document:  The use of methotrexate, colchicine, and other immunomodulatory drugs in the treatment of primary bi...