Document Detail

Ursodeoxycholic acid in primary biliary cirrhosis.
MedLine Citation:
PMID:  9170199     Owner:  NLM     Status:  MEDLINE    
In patients with primary biliary cirrhosis (PBC), ursodeoxycholic acid (ursodiol) improves laboratory test markers of cholestasis and hepatic inflammation as well as some hepatic histological features; it also delays histological progression in the early stages of PBC. Ursodiol is well tolerated and safe. Less well substantiated are that ursodiol either improves the quality of life or prevents liver transplantation or that it prolongs survival without transplantation. There are favorable trends for ursodiol in preventing transplantation and prolonging survival, but in the absence of randomized, placebo-controlled trials of sufficient duration, there remain impressions rather than statistically proved, strong conclusions.
B Combes
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Seminars in liver disease     Volume:  17     ISSN:  0272-8087     ISO Abbreviation:  Semin. Liver Dis.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110297     Medline TA:  Semin Liver Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235, USA.
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MeSH Terms
Cholagogues and Choleretics / therapeutic use*
Liver Cirrhosis, Biliary / drug therapy*
Liver Transplantation
Middle Aged
Quality of Life
Randomized Controlled Trials as Topic
Survival Analysis
Ursodeoxycholic Acid / therapeutic use*
Reg. No./Substance:
0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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