| Ursodeoxycholic acid in primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 9170199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with primary biliary cirrhosis (PBC), ursodeoxycholic acid (ursodiol) improves laboratory test markers of cholestasis and hepatic inflammation as well as some hepatic histological features; it also delays histological progression in the early stages of PBC. Ursodiol is well tolerated and safe. Less well substantiated are that ursodiol either improves the quality of life or prevents liver transplantation or that it prolongs survival without transplantation. There are favorable trends for ursodiol in preventing transplantation and prolonging survival, but in the absence of randomized, placebo-controlled trials of sufficient duration, there remain impressions rather than statistically proved, strong conclusions. |
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Authors:
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B Combes |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Seminars in liver disease Volume: 17 ISSN: 0272-8087 ISO Abbreviation: Semin. Liver Dis. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-25 Completed Date: 1997-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110297 Medline TA: Semin Liver Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 125-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas 75235, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholagogues and Choleretics
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therapeutic use* Female Humans Liver Cirrhosis, Biliary / drug therapy* Liver Transplantation Male Middle Aged Quality of Life Randomized Controlled Trials as Topic Survival Analysis Ursodeoxycholic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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