Document Detail


Ursodeoxycholic acid in patients with ulcerative colitis and primary sclerosing cholangitis for prevention of colon cancer: a meta-analysis.
MedLine Citation:
PMID:  22528343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE/AIM: Colon cancer risk is high in patients with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). Ursodeoxycholic acid has been shown to have some promise as a chemopreventive agent. A meta-analysis was performed to compare the efficacy of ursodeoxycholic acid in the prevention of colonic neoplasia in patients with UC and PSC.
METHODS: Multiple databases were searched (January 2011). Studies examining the use of ursodeoxycholic acid vs. no ursodeoxycholic acid or placebo in adult patients with UC and PSC were included. Data were extracted in standard forms by two independent reviewers. Meta-analysis for the effect of ursodeoxycholic acid was performed by calculating pooled estimates of adenoma or colon cancer formation by odds ratio (OR) with random effects model. Heterogeneity was assessed by calculating the I (2) measure of inconsistency. RevMan 5 was utilized for statistical analysis.
RESULTS: Four studies (n = 281) met the inclusion criteria. The studies were of adequate quality. Ursodeoxycholic acid demonstrated no overall improvement in adenoma (OR 0.53; 95 % CI: 0.19-1.48, p = 0.23) or colon cancer occurrence (OR 0.50; 95 % CI: 0.18-1.43, p = 0.20) as compared to no ursodeoxycholic acid or placebo in patients with UC and PSC.
CONCLUSION: Ursodeoxycholic acid use in patients with UC and PSC does not appear to decrease the risk of adenomas or colon cancer.
Authors:
Imran Ashraf; Abhishek Choudhary; Murtaza Arif; Michelle L Matteson; Hazem T Hammad; Srinivas R Puli; Matthew L Bechtold
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2012-04-14
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  31     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-06     Completed Date:  2012-11-06     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology and Hepatology, CE405, DC 043.00, University of Missouri Health Sciences Center, Five Hospital Drive, Columbia, MO 65212, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / prevention & control*
Cholagogues and Choleretics / therapeutic use*
Cholangitis, Sclerosing / complications,  drug therapy*
Colitis, Ulcerative / complications,  drug therapy*
Colonic Neoplasms / prevention & control*
Humans
Ursodeoxycholic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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