Document Detail


Ursodeoxycholic acid: Mechanism of action and novel clinical applications.
MedLine Citation:
PMID:  18034825     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, gallstone dissolution, and for patients with hepatitis C virus infection to ameliorate elevated alanine aminotransferase levels. The efficacy of UDCA treatment has been debated and the mechanisms of action in humans have still not defined. Suggested mechanisms include the improvement of bile acid transport and/or detoxification, cytoprotection, and anti-apoptotic effects. In this review, we summarize the proposed molecular mechanisms for the action of UDCA, especially in hepatocytes, and also discuss the putative future clinical usage of this unique drug.
Authors:
Tadashi Ikegami; Yasushi Matsuzaki
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Publication Detail:
Type:  Journal Article     Date:  2007-11-23
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  38     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  -    
Affiliation:
Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan.
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