Document Detail


Ursocholic acid, a hydrophilic bile acid, fails to improve liver function parameters in primary biliary cirrhosis: comparison with ursodeoxycholic acid.
MedLine Citation:
PMID:  9177526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the effect of short term feeding of ursocholic acid, a hydrophilic bile acid, as the unconjugated acid and the taurine conjugate, on clinical and biochemical features and bile acid metabolism with that of ursodeoxycholic acid in four patients with primary biliary cirrhosis. METHODS: Four patients with stage II primary biliary cirrhosis were studied. Two were fed ursocholic acid (900 mg/day), and two were given tauroursocholate (900 mg/day) in three divided doses. After 1 month, all patients were given 900 mg/day of ursodeoxycholic acid. Fasting serum, bile, and 24-hour urine levels were measured before and at the end of ursocholic acid and tauroursocholate feeding and after 1 month of ursodeoxycholic acid feeding. Clinical and biochemical symptoms were measured by routine hospital methods, and bile acids were measured by gas-liquid chromatography. RESULTS: One month of ursocholic acid or tauroursocholate feeding did not improve clinical or biochemical findings in any patient. Approximately 21-25% ursocholic acid was present in the serum and bile, with substantial metabolism to deoxycholic acid. Increased ursocholic acid was excreted in the urine. In comparison, ursodeoxycholic acid improved biochemical parameters and was 45-65% enriched in the serum and bile. CONCLUSION: Ursocholic acid as the free bile acid or as taurine conjugate, although more hydrophilic, is poorly enriched in serum and bile and is ineffective in patients with primary biliary cirrhosis.
Authors:
A K Batta; G Salen; J Abroon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1035-7     Citation Subset:  IM    
Affiliation:
Department of Medicine and Liver Institute, University of Medicine and Dentistry-New Jersey Medical School, Newark, USA.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bile / chemistry
Bile Acids and Salts / metabolism
Cholic Acids / administration & dosage,  blood,  therapeutic use*,  urine
Chromatography, Gas
Deoxycholic Acid / metabolism
Fasting
Female
Humans
Liver / drug effects*,  metabolism,  physiopathology
Liver Cirrhosis, Biliary / drug therapy*,  metabolism,  physiopathology
Placebos
Taurocholic Acid / administration & dosage,  blood,  therapeutic use,  urine
Ursodeoxycholic Acid / administration & dosage,  blood,  therapeutic use*,  urine
Grant Support
ID/Acronym/Agency:
CA-41108/CA/NCI NIH HHS; HL-17818/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 0/Placebos; 128-13-2/Ursodeoxycholic Acid; 2955-27-3/ursocholic acid; 81-24-3/Taurocholic Acid; 83-44-3/Deoxycholic Acid; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

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