| Urothromboplastin evidence for similarity between urothromboplastin and human brain thromboplastin. | |
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MedLine Citation:
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PMID: 6682214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urothromboplastin (UP) is a lipoprotein similar to Human Brain Thromboplastin (HBrTPL), the specific activity being bound to the presence of the whole complex. UP is found in normal human urine to be macroaggregates, therefore the substance is eluted from the Sepharose 2 B column immediately after the void volume and is found in the bottom of the tube after ultracentrifugation. In polyacrylamidgelelectrophoresis UP does not enter the gel and the UP activity can be eluted from the top of the gel. Natrium-desoxycholate reduces the activity of UP greatly, however after removal of this substance the original activity could be regained. There are similarities between UP and HBrTPL: In the same way as HBrTPL UP acts in the extrinsic pathway of the coagulation system, some evidence for binding of factor VII to UP in the presence of calcium could be found. Anti-apoprotein III antiserum (anti-HBrTPL antiserum) neutralizes UP, depending on the concentration of the antiserum. The same antiserum precipitates with UP using the immunodiffusion method. |
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Authors:
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G Mitterstieler; K Lechner; E Deutsch; P Margaritella; R Graninger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pädiatrie und Pädologie Volume: 18 ISSN: 0030-9338 ISO Abbreviation: Padiatr Padol Publication Date: 1983 |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0022370 Medline TA: Padiatr Padol Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 73-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoproteins
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immunology Blood Coagulation Factors / urine* Brain Chemistry Calcium / pharmacology Chromatography, Gel Electrophoresis, Polyacrylamide Gel Factor VII / metabolism Humans Immune Sera / immunology Plasminogen Activators / analysis Protein Binding Thromboplastin / urine* |
| Chemical | |
Reg. No./Substance:
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0/Apoproteins; 0/Blood Coagulation Factors; 0/Immune Sera; 7440-70-2/Calcium; 9001-25-6/Factor VII; 9035-58-9/Thromboplastin; EC 3.4.21.-/Plasminogen Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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