| Urothelial signaling. | |
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MedLine Citation:
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PMID: 21290228 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The urinary bladder "mucosa" or innermost portion of the bladder is composed of transitional epithelium, basement membrane, and the lamina propria. This chapter reviews the specialized anatomy of the bladder epithelium (urothelium) and speculates on possible communication mechanisms from urothelial cells to various cell types within the bladder wall. For example, beyond serving as a simple barrier, there is growing evidence that the urinary bladder urothelium exhibits specialized sensory properties and plays a key role in the detection and transmission of both physiological and nociceptive stimuli. Findings from a number of studies suggest that the urothelium exhibits both "sensor" (expressing receptors/ion channels capable of responding to thermal, mechanical, and chemical stimuli) and "transducer" (ability to release chemicals) properties. Thus, urothelial cells exhibit the ability to sense changes in their extracellular environment including the ability to respond to chemical, mechanical, and thermal stimuli that may communicate the state of the urothelial environment to the underlying nervous and muscular systems. |
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Authors:
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Lori A Birder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 207-31 Citation Subset: IM |
Affiliation:
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Departments of Medicine and Pharmacology, University of Pittsburgh School of Medicine, A 1207 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA, lbirder@pitt.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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