Document Detail

Urotensin-2 promotes collagen synthesis via ERK1/2-dependent and ERK1/2-independent TGF-β1 in neonatal cardiac fibroblasts.
MedLine Citation:
PMID:  20946103     Owner:  NLM     Status:  MEDLINE    
U2 (urotensin-2) is the most potent vasoconstrictor in mammals which is involved in cardiac remodelling, including cardiac hypertrophy and cardiac fibrosis. Although the cellular mechanisms of the U2-induced vasoconstriction have been extensively studied, the signalling pathways involved in U2-induced TGF-β1 (transforming growth factor-β1) expression and collagen synthesis remain unclear. In this study, we show that U2 promoted collagen synthesis and ERK1/2 (extracellular signal-regulated kinase 1/2) activation in neonatal cardiac fibroblasts. The U2-induced collagen synthesis and TGF-β1 production were significantly but not completely inhibited by blocking ERK1/2. Both ERK1/2 inhibitor and TGF-β1 antibody could separately inhibit U2-induced collagen synthesis, and the synergistic inhibition effect was observed by blocking ERK1/2 and TGF-β1 simultaneously. These data suggest that U2 promotes collagen synthesis via ERK1/2-dependent and independent TGF-β1 pathway in neonatal cardiac fibroblasts.
Hong-Yan Dai; Tao He; Xiao-Lu Li; Wen-Liang Xu; Zhi-Ming Ge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  35     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-05-03     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  93-8     Citation Subset:  IM    
Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, Peoples Republic of China.
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MeSH Terms
Animals, Newborn
Cells, Cultured
Collagen / biosynthesis*
Fibroblasts / metabolism*
Heart / growth & development
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3 / metabolism*
Myocardium / cytology
Rats, Wistar
Signal Transduction
Transforming Growth Factor beta1 / metabolism*
Urotensins / pharmacology*
Reg. No./Substance:
0/Transforming Growth Factor beta1; 0/Urotensins; 9007-34-5/Collagen; 9047-55-6/urotensin II; EC Protein Kinase 1; EC Protein Kinase 3

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