| Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway. | |
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MedLine Citation:
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PMID: 19896516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urotensin II (U-II) and its receptor are coexpressed in the heart and show various cardiovascular functions. However, the relationship between U-II and cardiac hormone atrial natriuretic peptide (ANP) is still unknown. The aim of the present study is to test whether U-II affects ANP secretion using in vitro perfusion experiments and in vivo studies. Human U-II (hU-II) (10(-11), 5x10(-11), 10(-10), 5x10(-10)M) stimulated ANP secretion from isolated perfused rat atria paced with high frequency (6.0Hz). However, atrial contractility and translocation of extracellular fluid (ECF) did not change. An increase in ANP secretion by rat U-II was similar to that by hU-II; however, urotensin-related peptide showed no significant effect on ANP secretion. Pretreatment with urotensin receptor antagonist and inhibitor for phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), or protein kinase C (PKC) attenuated hU-II-induced ANP secretion from atria paced with high frequency, but an inhibitor for inositol triphosphate did not. Intravenous infusion of hU-II at a dose of 2.5microM for 20min increased plasma ANP level, along with increased heart rate and pulse pressure in anesthetized rats. Therefore, we suggest that U-II stimulates high stimulation frequency-induced ANP secretion partly through the urotensin receptor and the PLC/PI3K/PKC pathway. |
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Authors:
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Shan Gao; Amin Shah; Young Bin Oh; Woo Hyun Park; Suhn Hee Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-05 |
Journal Detail:
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Title: Peptides Volume: 31 ISSN: 1873-5169 ISO Abbreviation: Peptides Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 164-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Diabetic Research Center, Chonbuk National University Medical School, Jeonju, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism* Animals Atrial Natriuretic Factor / secretion* Blood Pressure / drug effects Heart Atria / drug effects, metabolism Heart Rate / drug effects Hemodynamics / drug effects Humans Male Myocardial Contraction / drug effects, physiology Protein Kinase C / metabolism* Radioimmunoassay Rats Rats, Sprague-Dawley Signal Transduction / drug effects*, physiology Type C Phospholipases / metabolism* Urotensins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Urotensins; 85637-73-6/Atrial Natriuretic Factor; 9047-55-6/urotensin II; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.13/Protein Kinase C; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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