Document Detail

Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease.
MedLine Citation:
PMID:  16508659     Owner:  NLM     Status:  MEDLINE    
Urotensin II (UTN) is a vasoactive substance that may induce vasoconstriction or vasodilatation. Although this peptide is seen as a vasculotoxic substance, to date there is no prospective study examining the relationship between UTN and hard end points like cardiovascular (CV) events. UTN is much increased in end-stage renal disease (ESRD) and this disease may represent a useful natural model to explore the relationship between UTN and CV outcomes. In this study, we analysed the relationship between plasma UTN and incident CV events (fatal and non-fatal) in a cohort of 191 haemodialysis patients followed up for an average time of 3.6 years (range 0.07-5.8 years). Plasma UTN in haemodialysis patients (median: 6.5 ng/ml) was twice higher than in healthy subjects (median: 3.3 ng/ml). During the follow-up period, 94 patients died and 88 had incident fatal and non-fatal CV events. UTN was significantly lower in patients with incident CV events (median: 5.3 ng/ml) than in events-free patients (median: 7.1 ng/ml), and in a Kaplan-Meier analysis, high UTN was strongly and inversely associated with incident CV events (P<0.001). Multivariate Cox's regression analysis fully confirmed plasma UTN as an inverse predictor of adverse CV outcomes, and in this analysis, UTN resulted to be the third factor in rank, after age and diabetes, explaining the incidence of CV events. UTN is an inverse predictor of CV outcomes in ESRD. Our data suggest that UTN should not be necessarily seen as a vasculotoxic peptide in haemodialysis patients.
C Zoccali; F Mallamaci; G Tripepi; S Cutrupi; P Pizzini; L Malatino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  69     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-30     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1253-8     Citation Subset:  IM    
CNR-IBIM, Institute of Biomedicine, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension & Division of Nephrology, Dialysis and Transplantation, Reggio Calabria, Italy.
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MeSH Terms
Age Factors
Biological Markers / blood*
Cardiovascular Diseases / epidemiology*
Diabetic Angiopathies / epidemiology
Follow-Up Studies
Kidney Failure, Chronic / blood*,  complications
Middle Aged
Predictive Value of Tests
Reference Values
Urotensins / blood*
Reg. No./Substance:
0/Biological Markers; 0/Urotensins; 9047-55-6/urotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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