| Urotensin II in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 15921782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Human Urotensin II (hU-II) is the most potent vasoconstrictor known to date. HU-II receptors are predominant in the human heart and arterial vessels, suggesting hU-II to be of importance as a cardiovascular mediator. METHODS: We studied 32 consecutive patients (60+/-12 years) with chronic heart failure (CHF) and 10 control subjects (54+/-12 years, n.s.) with cardiopulmonary exercise testing. Blood samples for the measurement of plasma hU-II and big-endothelin-1 (big-ET1) were obtained at rest and at peak exercise. RESULTS: Peak VO(2) was significantly higher in controls than in CHF patients (19.8+/-3.8 vs. 14.7+/-3.6 ml min(-1) kg(-1), P<0.001). Big-ET1 levels were increased in CHF compared to controls at rest (2.8+/-1.8 vs. 1.7+/-0.1 fmol/ml, P<0.01) and at peak exercise (2.7+/-1.7 vs. 1.6+/-0.2 fmol/ml, P<0.005). HU-II concentrations were comparable in patients with CHF and controls at rest (2990+/-1104 vs. 3290+/-508 pg/ml, n.s.) and peak exercise (3063+/-1185 vs. 3213+/-1188 pg/ml, n.s.). Resting hU-II levels demonstrated no correlation with peak VO(2) in controls or CHF patients. CONCLUSIONS: The measurement of circulating plasma levels of hU-II does not seem to be very helpful in studying the effects of hU-II in human cardiovascular regulation. A local paracrine or autocrine mediator effect of hU-II in CHF is possible. |
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Authors:
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Stefan Krüger; Jürgen Graf; Dagmar Kunz; Tina Stickel; Marc W Merx; Peter Hanrath; Uwe Janssens |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 7 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-30 Completed Date: 2005-09-27 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 475-8 Citation Subset: IM |
Affiliation:
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Medical Clinic I and the Institute of Clinical Chemistry and Pathobiochemistry, University Hospital, University of Technology, Aachen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Endothelin-1 / blood Exercise / physiology Female Heart Failure / blood* Humans Male Middle Aged Oxygen Consumption Stroke Volume Urotensins / blood* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Urotensins; 9047-55-6/urotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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