Document Detail


Urotensin II immunoreactivity in the human circulation: evidence for widespread tissue release.
MedLine Citation:
PMID:  19797715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The sources of secretion and clearance of plasma urotensin II (UII) in the human circulation remain uncertain and may be relevant to understanding the role of UII in human physiology and cardiovascular disease. METHODS: In 94 subjects undergoing clinically indicated cardiac catheterization, we collected blood samples from arterial and multiple venous sites to measure transorgan gradients of plasma UII immunoreactivity. RESULTS: Net UII release occurred (in descending order of proportional transorgan gradient) across the heart, kidney, head and neck, liver, lower limb, and pulmonary circulations (P < 0.01). Although no specific clearance site was localized, the absence of an overall subdiaphragmatic aorto-caval peptide gradient indicated that there were lower body segment sites of UII clearance as well as secretion. The proportional increase in UII immunoreactivity was significantly correlated across all sites of net peptide release within an individual (P < or = 0.05). In univariate analyses, mixed venous UII concentrations were correlated with diagnosis of acute coronary syndrome and femoral artery oxygen tension and inversely with systolic blood pressure and body mass index. Diagnosis of acute coronary syndrome and body mass index were independent predictors of mixed venous UII immunoreactivity in multivariate analysis. No correlates of net cardiac UII release were identified. CONCLUSIONS: UII is secreted from the heart and multiple other tissues into the circulation. Related increments in UII immunoreactivity across multiple tissue sites suggest that peptide release occurs via a shared mechanism. Increased UII immunoreactivity is observed in subjects with acute coronary syndrome.
Authors:
Yen-Hsing Chen; Timothy G Yandle; A Mark Richards; Suetonia C Palmer
Related Documents :
18022915 - Chronic pulmonary thromboembolism in a patient with a fontan circulation: percutaneous ...
2591355 - The effect of unilateral resection of segments of both palmar digital arteries on the n...
3675505 - Central and coronary circulation of the normal man during orthostatic and lower body ne...
21718915 - Vitamin d status is associated with arterial stiffness and vascular dysfunction in heal...
12925265 - Shunt migration into the sphenoid sinus: case report.
12118765 - Lvad support in patients with bioprosthetic valves.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-01
Journal Detail:
Title:  Clinical chemistry     Volume:  55     ISSN:  1530-8561     ISO Abbreviation:  Clin. Chem.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-29     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2040-8     Citation Subset:  IM    
Affiliation:
Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch 8140, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood,  diagnosis
Aged
Blood Circulation
Blood Pressure
Body Mass Index
Female
Heart Catheterization
Humans
Male
Middle Aged
Multivariate Analysis
Oxygen / blood
Urotensins / blood*,  immunology*
Chemical
Reg. No./Substance:
0/Urotensins; 7782-44-7/Oxygen; 9047-55-6/urotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Library of Prefabricated Locked Nucleic Acid Hydrolysis Probes Facilitates Rapid Development of Reve...
Next Document:  Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients car...