Document Detail

Urological applications of human papillomavirus typing using deoxyribonucleic acid probes for the diagnosis and treatment of genital condyloma.
MedLine Citation:
PMID:  2908958     Owner:  NLM     Status:  MEDLINE    
The use of deoxyribonucleic acid probes to examine the type of the human papillomavirus genome found in penile lesions is described at a technical level and in a clinical application. At least 40 different types of human papillomavirus have been identified and these types vary not only in their deoxyribonucleic acid base sequences but also in their clinical manifestations. Although deoxyribonucleic acid probes currently have a role only in a research setting, this study delineates the possible role of this technology in a clinical setting to detect subclinical intraurethral human papillomavirus. The results have widespread implications regarding the treatment of condyloma and the associated cervical dysplasia. In this series 25 grossly visible lesions were typed and 85 per cent contained human papillomavirus types 6 and 11. In contrast, microscopic lesions identified in the male partners of women with cervical dysplasia were shown to contain human papillomavirus types 16, 18 or 31 in 60 per cent of the cases. In addition, urethral brushings were obtained and were positive for human papillomavirus in 50 per cent of the cases despite normal urethroscopy. Human papillomavirus types 16, 18 or 31 accounted for 70 per cent of the positive urethral brushings.
S A Zderic; V L Carpiniello; T R Malloy; R F Rando
Related Documents :
322608 - Requirements of glucose and incubation under static conditions for optimal colicin e1 i...
25399968 - A simple digestion method with a lefort aqua regia solution for diatom extraction.
4725618 - Studies on the developmental cycle of chlamydia trachomatis: selective inhibition by hy...
53248 - The influence of chromatin compactness on the stoichiometry of the feulgen-schiff proce...
18572518 - Determination of atmospheric hydroxyl radical by hplc coupled with electrochemical dete...
11886758 - Synthesis of polyhydroxyalkanoate in the peroxisome of pichia pastoris.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  141     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-5     Citation Subset:  AIM; IM    
Department of Urology, Pennsylvania Hospital, Philadelphia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Condylomata Acuminata / diagnosis*
DNA Probes*
DNA Probes, HPV*
Penile Neoplasms / diagnosis*
Urethral Neoplasms / diagnosis*
Uterine Cervical Dysplasia / etiology
Reg. No./Substance:
0/DNA Probes; 0/DNA Probes, HPV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inflatable penile prostheses in patients undergoing cystoprostatectomy with urethrectomy.
Next Document:  Radiographic assessment of the vesicourethral anastomosis directing early decatheterization followin...