Document Detail

Urologic tissue engineering in pediatrics: from nanostructures to bladders.
MedLine Citation:
PMID:  20075760     Owner:  NLM     Status:  MEDLINE    
The use of tissue engineering to develop new urinary bladder could have direct impact on children suffering from congenital bladder dysfunction. Current bladder tissue engineering protocols rely on scaffolds to support the ingrowth of new cells and the subsequent development of new tissues. The interaction between cells and scaffolds is mediated on the molecular level and nanotechnology is being investigated as a means to improve the biocompatibility of these scaffolds. In this review, we will discuss the current applications of nanotechnology for bladder tissue engineering; specifically, the use of selective degradation techniques and self-assembly molecules to create nanofeatures on existing scaffolds, the use of electrospinning to create de novo scaffolds, and the use of nanoparticles as a drug delivery system will be discussed. The use of nanotechnology has resulted in novel tissue engineering protocols and is likely to be an important factor in the eventual clinical application of tissue engineering for the urinary bladder.
Christopher C Roth
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Department of Urology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70118, USA.
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MeSH Terms
Cell Differentiation
Cell Proliferation
Drug Delivery Systems
Extracellular Matrix / metabolism
Pediatrics / methods*
Tissue Engineering*
Tissue Scaffolds*
Urinary Bladder / anatomy & histology,  physiology*

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