| Urokinase thrombolysis as initial therapy for acute and non-acute ischemic extremities. | |
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MedLine Citation:
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PMID: 9009854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Limb ischemia, both acute and chronic, presents a risk to life and limb with mortality rates from 3% to 37% and amputation rates of the same range. Our experience with urokinase thrombolysis as the initial therapy for acute and non-acute ischemic extremities over 57 consecutive cases of native arterial occlusion by either thrombus or embolus has resulted in no mortality and only 3.5% requiring amputation (2 of 57). In 74% of cases initial thrombolytic therapy was followed by either balloon angioplasty (35 patients) or surgery (7 patients) to relieve the underlying cause of obstruction (i.e., stenosis, occlusion or aneurysm). Thrombolysis alone was sufficient and effective treatment in the remaining 26% (15 patients). |
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Authors:
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D Byrne; W D Byrne; P D Kiernan; W Harshaw; J Bryne; T Fulcher; L Stanton; S Goodman; M Karnaze |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virginia medical quarterly : VMQ Volume: 124 ISSN: 1052-4231 ISO Abbreviation: Va Med Q Publication Date: 1997 |
Date Detail:
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Created Date: 1997-02-20 Completed Date: 1997-02-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9104333 Medline TA: Va Med Q Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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INOVA Health System, Fairfax Hospital, VA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Balloon Arterial Occlusive Diseases / drug therapy* Female Fibrinolytic Agents / administration & dosage, therapeutic use* Humans Ischemia / drug therapy*, etiology, therapy Leg / blood supply Male Middle Aged Urokinase-Type Plasminogen Activator / administration & dosage, therapeutic use* Vascular Surgical Procedures |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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