| Uroguanylin: how the gut got another satiety hormone. | |
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MedLine Citation:
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PMID: 21865649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI, Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS, which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity. |
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Authors:
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Randy J Seeley; Matthias H Tschöp |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2011-08-25 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-01 Completed Date: 2011-10-31 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 3384-6 Citation Subset: AIM; IM |
Affiliation:
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Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA. randy.seeley@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology* Eating* Endocrine System / metabolism* Feeding Behavior / physiology* Female Male Natriuretic Peptides / metabolism* Receptors, Guanylate Cyclase-Coupled / metabolism* Receptors, Peptide / metabolism* Second Messenger Systems / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK54890/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides; 0/Receptors, Peptide; 152175-68-3/uroguanylin; EC 4.6.1.2/Receptors, Guanylate Cyclase-Coupled; EC 4.6.1.2/enterotoxin receptor |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2011 Sep;121(9):3578-88
[PMID:
21865642
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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