| Urocortin protects against ischemic injury via a MAPK-dependent pathway. | |
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MedLine Citation:
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PMID: 11597826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urocortin (UCN), is a peptide related to hypothalamic corticotrophin releasing hormone (CRF) and binds with high affinity to the CRF-R2 beta receptor which is expressed in the heart. UCN prevents cell death when administered to primary cardiac myocyte cultures both prior to simulated hypoxia/ischemia and at the point of reoxygenation after simulated hypoxia/ischemia as assayed by trypan blue exclusion. 3'-OH end labeling of DNA (TUNEL), annexin-V and fluorescence activated cell sorting. The protective effect of UCN is dependent on the p42/p44 mitogen-activated protein kinase (MAPK)-pathway. UCN also reduces damage in isolated rat hearts ex vivo, subjected to regional ischemia/reperfusion with the protective effect being observed when UCN is given either prior to ischemia or at the time of reperfusion after ischemia. Hence, UCN is a cardioprotective agent, which acts when given prior to ischemia or after ischemia at reperfusion. |
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Authors:
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D S Latchman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 11 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-10-12 Completed Date: 2001-12-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 167-9 Citation Subset: IM |
Affiliation:
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Institute of Child Health, University College London, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corticotropin-Releasing Hormone / metabolism*, therapeutic use* Mitogen-Activated Protein Kinases / metabolism* Myocardial Ischemia / drug therapy, metabolism, prevention & control* Protective Agents / metabolism*, therapeutic use* Rats Receptors, Corticotropin-Releasing Hormone / metabolism Urocortins |
| Chemical | |
Reg. No./Substance:
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0/CRF receptor type 2; 0/Protective Agents; 0/Receptors, Corticotropin-Releasing Hormone; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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