Document Detail


Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats.
MedLine Citation:
PMID:  19463744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Urocortin (UCN), a newly isolated corticotrophin-releasing factor (CRF) related peptide, has been found to have potent cardiovascular protective effects. This study aimed to investigate the long-term effects of UCN on arterial remodeling and related functional alterations. UCN (7 microg/kg/d) was administered to spontaneously hypertensive rats (SHR) for 8 weeks. Systolic blood pressure (SBP) was measured weekly. Functional studies were performed on isolated mesenteric arterial segments. Also, by light microscope and electron microscope, the morphology of mesenteric arteries was examined. Our results showed that mean SBP in UCN-treated SHRs was about 40 mm Hg lower than that of the control SHR group, and was similar to that of the enalapril-treated group. In the mesenteric arterial segments pre-contracted with norepinephrine (0.001-10 microM), the maximal relaxation rate induced by acetylcholine (10 microM) in UCN-treated group (about 93.3%) was higher than that in SHR control group (about 40.0%) (n=6, P<0.01). Furthermore examination under light microscope showed that UCN (3.5 microg/kg/d) treatment significantly reduced media thickness, media/lumen ratio, resulting in larger lumen diameter while analysis of transmission electron microscopic findings revealed that chromatin, internal elastic lamina and densely packed mitochondria displayed a close-to-normal distribution after UCN treatment. These results suggested that long-term UCN treatment not only had hypotensive effects but may also inhibited development of vascular remodeling in mesenteric arteries in SHR.
Authors:
Jiandong Chen; Jin Tao; Rongjian Zhang; Youhua Xu; Tuckwah Soong; Shengnan Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-06
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1117-23     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Nanjing Medical University, Nanjing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Mesenteric Arteries / drug effects*,  pathology
Microscopy, Electron
Norepinephrine / pharmacology
Rats
Rats, Inbred SHR
Time Factors
Urocortins / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Urocortins; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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