Document Detail


Urocortin 3: haemodynamic, hormonal, and renal effects in experimental heart failure.
MedLine Citation:
PMID:  16825287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To investigate the haemodynamic, hormonal, and renal effects of peripheral urocortin 3 (Ucn3) administration for the first time in either normal health or heart failure (HF). METHODS AND RESULTS: Eight sheep received incremental intravenous boli of Ucn3 (10, 50, and 100 microg at 2-h intervals) before (normal) and during pacing-induced HF. Compared with controls, Ucn3 induced immediate, dose-dependent increases in cardiac output (normal 4.21+/-0.23 vs. 5.65+/-0.32 L/min, P<0.001; HF 2.20+/-0.14 vs. 4.43+/-0.31 L/min, P < 0.001) and decreases in peripheral resistance (normal 20.8+/-1.0 vs. 16.2+/-0.8 mmHg/L/min, P < 0.01; HF 34.4+/-1.7 vs. 16.2+/-0.5 mmHg/L/min, P < 0.001) and left atrial pressure (normal 4.5+/-0.3 vs. 0.6+/-0.2 mmHg, P < 0.001; HF 23.0+/-0.6 vs. 5.8+/-1.9 mmHg/L/min, P < 0.001). Arterial pressure was minimally elevated in normals (P < 0.001) and reduced in HF (P < 0.05). In HF only, Ucn3 decreased plasma vasopressin (3.33+/-0.36 vs. 1.73+/-0.21 pmol/L, P < 0.05), endothelin-1 (3.56+/-0.28 vs. 2.64+/-0.24 pmol/L, P < 0.001), renin (2.74+/-1.17 vs. 1.04+/-0.22 nmol/L/h, P < 0.001), aldosterone (1494+/-400 vs. 726+/-168 pmol/L, P < 0.05), and epinephrine (1608+/-278 vs. 1039+/-75 pmol/L, P < 0.05), and increased urine output (P < 0.05), sodium excretion (P < 0.01), and creatinine clearance (P < 0.05). CONCLUSION: Ucn3 has significant cardiovascular effects in normal and HF sheep, supporting a role for this peptide in circulatory regulation. In HF, more prominent haemodynamic changes were associated with beneficial endocrine and renal effects, suggesting Ucn3 has therapeutic potential in this disease.
Authors:
Miriam T Rademaker; Vicky A Cameron; Chris J Charles; A Mark Richards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-06
Journal Detail:
Title:  European heart journal     Volume:  27     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2007-03-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2088-98     Citation Subset:  IM    
Affiliation:
Christchurch Cardioendocrine Research Group, The Christchurch School of Medicine, PO Box 4345, Christchurch 8001, New Zealand. miriam.rademaker@chmeds.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Animals
Corticotropin-Releasing Hormone / administration & dosage,  pharmacology*
Electrolytes / blood,  urine
Female
Heart Failure / drug therapy*,  physiopathology
Heart Rate / drug effects*
Hematocrit
Hormones / metabolism*
Sheep
Urocortins
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Electrolytes; 0/Hormones; 0/UCN3 protein, human; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone

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