Document Detail

Urocortin 1 and 3 impair maternal defense behavior in mice.
MedLine Citation:
PMID:  16187834     Owner:  NLM     Status:  MEDLINE    
Lactating female mice fiercely defend offspring while exhibiting decreased fear and anxiety. Recent work (J. S. Lonstein & S. C. Gammie, 2002) found that intracerebroventricular (icv) injections of corticotropin releasing factor (CRF), a putative anxiogenic peptide, inhibit maternal defense behavior. This study examines effects of CRF-related peptides, urocortin (Ucn) 1 and Ucn 3, on maternal aggression in mice. Intracerebroventricular injections of both Ucn 1 (0.2 microg) and Ucn 3 (0.5 microg) reduced aggression but not pup retrieval. c-Fos levels were elevated by intracerebroventricular injections of Ucn 1 (0.2 microg) and Ucn 3 (0.5 microg) in 2 and 6 brain regions, respectively; however, both triggered increases in bed nucleus of the stria terminalis dorsal (BNSTd) and lateral septum (LS). These findings suggest that CRF-related peptides similarly modulate maternal aggression and that BNSTd/LS may be critical sites for negative regulation of maternal aggression.
Kimberly L D'Anna; Sharon A Stevenson; Stephen C Gammie
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  119     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-01-23     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1061-71     Citation Subset:  IM    
Copyright Information:
(c) 2005 APA
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MeSH Terms
Aggression / drug effects*,  physiology
Analysis of Variance
Behavior, Animal / drug effects
Cell Count / methods
Corticotropin-Releasing Hormone / pharmacokinetics*,  pharmacology*
Dose-Response Relationship, Drug
Gene Expression Regulation / drug effects
Immunohistochemistry / methods
Injections, Intraventricular / methods
Maternal Behavior / drug effects*,  physiology
Mice, Inbred ICR
Proto-Oncogene Proteins c-fos / metabolism
Septal Nuclei / drug effects,  physiology
Grant Support
R01 MH066086/MH/NIMH NIH HHS; R01 MH066086/MH/NIMH NIH HHS; R01 MH066086-04/MH/NIMH NIH HHS
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Urocortins; 9015-71-8/Corticotropin-Releasing Hormone
Comment In:
Behav Neurosci. 2005 Aug;119(4):1165-8   [PMID:  16187848 ]

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