Document Detail

Urocanic acid isomers in patients with non-melanoma skin cancer.
MedLine Citation:
PMID:  11298549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cis-urocanic acid (cis-UCA), formed from the naturally occurring trans-isomer in the epidermis on ultraviolet (UV) radiation, initiates some of the changes leading to UV-induced immunosuppression, but its role in cutaneous carcinogenesis has not been fully investigated. OBJECTIVES: To measure the concentration of UCA isomers in the photoexposed and non-photoexposed skin of patients with multiple non-melanoma skin cancer (NMSC), enrolled in different periods of the year, in comparison with control subjects. PATIENTS/METHODS: UCA isomers were determined by high-performance liquid chromatography analysis in samples from the outer arm (photoexposed site) and buttock (non-photoexposed site) obtained from 20 patients and 19 controls during the winter period (October to April), and from five patients and 11 controls during the summer period (June to September). RESULTS: In the winter months, no difference was found between patients and controls in the concentration of UCA or the percentage of cis-UCA in either site. In the summer months, the percentage of cis-UCA in the buttock of patients and controls was similar but it was significantly higher in the arm of the controls (42%) than in the patients (17%). CONCLUSIONS: We conclude that different behaviour regarding sun exposure is the most likely explanation for these results, and that the concentration of UCA and its isomers does not reflect a tendency for individuals to develop NMSC.
C De Simone; C Masini; M S Cattaruzza; C Guerriero; D Cerimele; M Norval
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  144     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  858-61     Citation Subset:  IM    
Department of Dermatology, Universita Cattolica S. Cuore, L.go A. Gemelli, 8-00168 Roma, Italy.
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MeSH Terms
Carcinoma, Basal Cell / chemistry*
Carcinoma, Squamous Cell / chemistry*
Middle Aged
Skin / chemistry,  radiation effects
Skin Neoplasms / chemistry*
Urocanic Acid / analysis*
Reg. No./Substance:
104-98-3/Urocanic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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