Document Detail

Urocanic acid isomers are good hydroxyl radical scavengers: a comparative study with structural analogues and with uric acid.
MedLine Citation:
PMID:  10366766     Owner:  NLM     Status:  MEDLINE    
UV-exposure of the epidermis leads to the isomerisation of trans-UCA into cis-UCA as well as to the generation of hydroxyl radicals. This study shows by means of the deoxyribose degradation test that UCA isomers are more powerful hydroxyl radical scavengers than the other 4-(5-)substituted imidazole derivatives, such as histidine, though less powerful than uric acid. UCA, present in relatively high concentrations in the epidermis, may well be a major natural hydroxyl radical scavenger.
A Kammeyer; T A Eggelte; J D Bos; M B Teunissen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1428     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Department of Dermatology, Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
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MeSH Terms
Free Radical Scavengers / chemistry*
Hydroxyl Radical / chemistry*
Molecular Structure
Skin / chemistry,  radiation effects*
Uric Acid / chemistry*
Urocanic Acid / analogs & derivatives,  chemistry*
Reg. No./Substance:
0/Free Radical Scavengers; 104-98-3/Urocanic Acid; 3352-57-6/Hydroxyl Radical; 533-67-5/Deoxyribose; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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