Document Detail


Urocanic acid isomers are good hydroxyl radical scavengers: a comparative study with structural analogues and with uric acid.
MedLine Citation:
PMID:  10366766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
UV-exposure of the epidermis leads to the isomerisation of trans-UCA into cis-UCA as well as to the generation of hydroxyl radicals. This study shows by means of the deoxyribose degradation test that UCA isomers are more powerful hydroxyl radical scavengers than the other 4-(5-)substituted imidazole derivatives, such as histidine, though less powerful than uric acid. UCA, present in relatively high concentrations in the epidermis, may well be a major natural hydroxyl radical scavenger.
Authors:
A Kammeyer; T A Eggelte; J D Bos; M B Teunissen
Related Documents :
843466 - The effect of normal pregnancy upon the renal handling of uric acid.
2955866 - Characteristics of the labile neurotoxin associated with nervous coccidiosis.
886556 - Renal urate excretion in five cases of hypouricemia with an isolated renal defect of ur...
18709966 - Epidemiological survey of hyperuricemia as an adverse reaction to antituberculous thera...
19886426 - Effect of loading rate and hrt on the removal of cephalosporin and their intermediates ...
8456596 - Nasu-hakola disease. a case accompanied by abnormalities in fatty acid composition of s...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1428     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. a.kammeyer@amc.uva.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Deoxyribose
Free Radical Scavengers / chemistry*
Humans
Hydroxyl Radical / chemistry*
Isomerism
Molecular Structure
Skin / chemistry,  radiation effects*
Uric Acid / chemistry*
Urocanic Acid / analogs & derivatives,  chemistry*
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 104-98-3/Urocanic Acid; 3352-57-6/Hydroxyl Radical; 533-67-5/Deoxyribose; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sialic acid-specific lectin from Tritrichomonas foetus.
Next Document:  Role of glutathione on acrolein-induced cytotoxicity and mutagenicity in Escherichia coli.