| Urocanic acid in the skin: a mixed blessing? | |
| | |
MedLine Citation:
|
PMID: 21157424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative "natural sunscreen" and later as a mediator of photoimmunosuppression with a consequent role in photocarcinogenesis. For the first time, Barresi and colleagues provide robust evidence for the photoprotective role of endogenous urocanic acid and reopen the debate on the relative "beneficial" and "detrimental" properties of this molecule. |
| | |
Authors:
|
Neil K Gibbs; Mary Norval |
Related Documents
:
|
1249054 - Avian mitochondrial glutamine metabolism. 12558024 - A glass capillary microelectrode based on capillarity and its application to the detect... 1063064 - Amino acid metabolism of platelets in leukemia. 4844274 - Physiology of sporeforming bacteria associated with insects: minimal nutritional requir... 17964214 - Effects of bile acids on expression of the human apical sodium dependent bile acid tran... 20484014 - Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins... |
Publication Detail:
|
Type: Comment; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of investigative dermatology Volume: 131 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-15 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 14-7 Citation Subset: IM |
Affiliation:
|
Dermatological Sciences, University of Manchester, Manchester, UK. neil.gibbs@manchester.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Epidermis / immunology, metabolism*, radiation effects Humans Immune Tolerance / physiology*, radiation effects Skin Neoplasms / immunology, metabolism* Sunlight / adverse effects* Urocanic Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
104-98-3/Urocanic Acid |
| Comments/Corrections | |
Comment On:
|
J Invest Dermatol. 2011 Jan;131(1):188-94
[PMID:
20686493
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Eczema across the world: the missing piece of the jigsaw revealed.
Next Document: Lymphangiogenesis linked to VEGF-C from tumor-associated macrophages: accomplices to metastasis by c...