Document Detail

Urine production in the halothane anesthetized rabbit.
MedLine Citation:
PMID:  515479     Owner:  NLM     Status:  MEDLINE    
Urine and blood parameters were studied in rabbits subjected to anesthesia and abdominal surgery. Conscious control animals both fasted and fed to which water was freely available were used for comparison. During anesthesia and operation one group of animals were given no intravenous fluid, other groups were infused with normal saline at a rate of 0.5 ml, 1 ml, or 2 ml per minute. The results demonstrated that an intravenous saline infusion of 0.5 ml per minute, maintains an essentially normal state of hydration and is beneficial to rabbits during anesthesia and surgery. However, with such an infusion, the rabbits do not produce urine under the experimental conditions. Higher rates of infusion are associated with a declining heart rate and blood pressure, abnormal urine, and metabolic acidosis. We conclude that the rabbit is an inappropraite species for renal studies involving anesthesia and surgery.
J C Russell; B F Litchfield; D C Secord
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revue canadienne de biologie / éditée par l'Université de Montréal     Volume:  38     ISSN:  0035-0915     ISO Abbreviation:  Rev Can Biol     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-02-28     Completed Date:  1980-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8214595     Medline TA:  Rev Can Biol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Halothane / pharmacology*
Heart Rate / drug effects
Infusions, Parenteral
Osmolar Concentration
Sodium Chloride
Urination / drug effects*
Reg. No./Substance:
151-67-7/Halothane; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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