Document Detail


Urine phthalate determinations as an index of occupational exposure to phthalic anhydride and di(2-ethylhexyl)phthalate.
MedLine Citation:
PMID:  4071004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although it has been estimated that over 600 000 workers in the United States are exposed to di(2-ethylhexyl)phthalate (DEHP), an animal carcinogen, and that over 100 000 are exposed to phthalic anhydride (PA), few data are available on levels of phthalates in biological fluids of these workers. For a determination of occupational exposure to PA and DEHP at a plant manufacturing DEHP from PA and 2-ethylhexanol, air samples were taken for PA and DEHP, and pre- and postshift urine samples were collected for the determination of total phthalates. Urine samples were obtained from 48 workers in jobs with high exposure to phthalates and from 47 workers in jobs with low exposure. The airborne concentrations of DEHP ranged from 20 to 4 110 micrograms/m3, and the concentrations of PA ranged from 4 to 203 micrograms/m3. The most heavily exposed workers had the highest mean postshift urine phthalate concentration (geometric mean 7.6 nmol/ml) (p = 0.015), and also the greatest mean increase (4.4 nmol/ml) in preshift to postshift urine phthalate levels. Twofold increases over the shift in urine phthalate concentration and postshift phthalate levels of greater than 10 nmol/ml were observed in 8 (25%) of 32 chemical operators, but in none of 52 other workers. These data suggest that measurement of urine phthalate levels may have utility for monitoring the exposure of workers manufacturing or using PA.
Authors:
G M Liss; P W Albro; R W Hartle; W T Stringer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  11     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-01-14     Completed Date:  1986-01-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  381-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants, Occupational / analysis*
Chemical Phenomena
Chemistry
Diethylhexyl Phthalate / analysis*
Humans
Phthalic Acids / analysis*,  urine*
Phthalic Anhydrides / analysis*
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Phthalic Acids; 0/Phthalic Anhydrides; 117-81-7/Diethylhexyl Phthalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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