Document Detail


Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction.
MedLine Citation:
PMID:  22049182     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Urinary tract obstruction (UTO) is a common problem that can lead to permanent loss of kidney function. Unilateral UTO may be difficult to diagnose. Urinary neutrophil gelatinase-associated Lipocalin (uNGAL) may identify unilateral and bilateral UTO.
METHODS: Retrospective case-control study of patients undergoing hospital admission at three sites. UTO was determined by review of medical records and cases were matched to control patients. uNGAL was measured by immunoblot.
RESULTS: Twenty-four unilateral UTO and 15 bilateral UTO cases were identified. Admission serum creatinine (sCr) (milligram per decilitre) was significantly higher in bilateral UTO, 2.0 (1.1-5.3), but not unilateral UTO, 1.1 (0.8-1.5), compared to controls, 0.9 (0.8-1.2). uNGAL (nanogram per millilitre) was significantly higher both in patients with bilateral UTO, 140 (40-450), and unilateral UTO, 50 (20-100), compared to controls, 20 (10-45).
DISCUSSION: uNGAL identifies kidney injury in unilateral and bilateral UTO even in the absence of an elevated sCr.
Authors:
Meghan E Sise; Catherine Forster; Eugenia Singer; David Sola-Del Valle; Barry Hahn; Kai M Schmidt-Ott; Jonathan Barasch; Thomas L Nickolas
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-01
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  26     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-09-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  4132-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Columbia University, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / urine*
Aged
Case-Control Studies
Female
Humans
Lipocalins / urine*
Male
Middle Aged
Proto-Oncogene Proteins / urine*
Retrospective Studies
Urethral Obstruction / diagnosis*,  pathology,  urine*
Urinary Bladder Neck Obstruction / diagnosis*,  pathology,  urine*
Grant Support
ID/Acronym/Agency:
K23 DK080139/DK/NIDDK NIH HHS; R01DK073462-06/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins
Comments/Corrections

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