| Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction. | |
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MedLine Citation:
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PMID: 22049182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Urinary tract obstruction (UTO) is a common problem that can lead to permanent loss of kidney function. Unilateral UTO may be difficult to diagnose. Urinary neutrophil gelatinase-associated Lipocalin (uNGAL) may identify unilateral and bilateral UTO. METHODS: Retrospective case-control study of patients undergoing hospital admission at three sites. UTO was determined by review of medical records and cases were matched to control patients. uNGAL was measured by immunoblot. RESULTS: Twenty-four unilateral UTO and 15 bilateral UTO cases were identified. Admission serum creatinine (sCr) (milligram per decilitre) was significantly higher in bilateral UTO, 2.0 (1.1-5.3), but not unilateral UTO, 1.1 (0.8-1.5), compared to controls, 0.9 (0.8-1.2). uNGAL (nanogram per millilitre) was significantly higher both in patients with bilateral UTO, 140 (40-450), and unilateral UTO, 50 (20-100), compared to controls, 20 (10-45). DISCUSSION: uNGAL identifies kidney injury in unilateral and bilateral UTO even in the absence of an elevated sCr. |
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Authors:
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Meghan E Sise; Catherine Forster; Eugenia Singer; David Sola-Del Valle; Barry Hahn; Kai M Schmidt-Ott; Jonathan Barasch; Thomas L Nickolas |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-11-01 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-28 Completed Date: 2012-09-13 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 4132-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Columbia University, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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urine* Aged Case-Control Studies Female Humans Lipocalins / urine* Male Middle Aged Proto-Oncogene Proteins / urine* Retrospective Studies Urethral Obstruction / diagnosis*, pathology, urine* Urinary Bladder Neck Obstruction / diagnosis*, pathology, urine* |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK080139/DK/NIDDK NIH HHS; R01DK073462-06/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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