Document Detail


Urine mercury excretion following meso-dimercaptosuccinic acid challenge in fish eaters.
MedLine Citation:
PMID:  19123743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Public awareness of methylmercury in fish has caused patients to seek testing for mercury poisoning. In some patients, the diagnosis of mercury poisoning has been made based on urine mercury excretions following oral dosing of meso-dimercaptosuccinic acid (DMSA), a metal chelator. However, studies comparing urine mercury excretion following DMSA in healthy non-fish eaters with healthy fish eaters could not be located. OBJECTIVES: To describe urinary mercury excretion before and after DMSA in healthy fish eaters and non-fish eaters, and to determine whether urine mercury excretion after DMSA would rise above baseline levels to a greater extent in fish eaters. DESIGN: A total of 24 healthy physicians were assigned to 1 of 3 groups based on fish consumption: non-fish eaters; 1 to 2 fish servings per week; and 3 or more servings per week. Blood mercury concentrations and 12-hour urine mercury and creatinine excretions were measured before and after oral ingestion of 30 mg of DMSA per kilogram of body weight. RESULTS: A total of 24 subjects completed the study, and 2 subsequently were excluded. No difference in baseline urinary mercury excretion was detected between groups. All groups demonstrated an increase in urinary mercury excretion following DMSA, which was higher in fish eaters (P = .04). Multiple linear regression found that the best predictor of a rise in urine mercury excretion following DMSA challenge was the prechelation blood mercury concentration. CONCLUSIONS: In this study of healthy physicians, oral DMSA produced a rise in urine mercury excretion both in non-fish eaters and fish eaters. The increase in chelated mercury excretion was higher in fish eaters. A simple rise in chelated mercury excretion over baseline excretion is not a reliable diagnostic indicator of mercury poisoning.
Authors:
Anne-Michelle Ruha; Steven C Curry; Richard D Gerkin; Kathleen L Caldwell; John D Osterloh; Paul M Wax
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  133     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA. michelle.ruha@bannerhealth.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Animals
Body Burden
Chelating Agents / diagnostic use*
Diet
Environmental Exposure*
Female
Fishes
Food Habits*
Humans
Male
Mercury / blood,  urine*
Mercury Poisoning / diagnosis,  urine
Middle Aged
Seafood*
Succimer / diagnostic use*
Chemical
Reg. No./Substance:
0/Chelating Agents; 304-55-2/Succimer; 7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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