Document Detail

Urine neural thread protein measurements in Alzheimer disease.
MedLine Citation:
PMID:  21450171     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Neural thread protein (NTP), a membrane-associated phosphoprotein, was selectively elevated in the urine of patients with Alzheimer disease (AD). To demonstrate the potential utility of urine NTP assays for the diagnosis of AD, we performed this study.
DESIGN: A prospective blinded multicentered study.
PARTICIPANTS: Individuals diagnosed as having probable AD (n = 49), Parkinson's disease (PD) (n = 20), and healthy controls (n = 22) were enrolled consecutively in 4 neurology centers.
MEASUREMENTS: A first morning urine sample was obtained from each subject. Urine NTP measurement using competitive ELISA was tested at the central laboratory and compared with AD and PD patients and healthy controls (HC). The testing laboratory was blinded to clinical information.
RESULTS: The mean assay value in AD (n = 49, 26.8 ± 9.4 μg/mL) was significantly higher than in HC (n = 22, 18.1 ± 6.7 μg/mL) (P ≤ .001) and than in PD (n = 20, 21.0 ± 8.5 μg/mL) (P ≤ .05). Levels of 21.6 μg/mL or higher were found in 81.6% of all AD cases, in 30.0% of PD cases, and in 13.6% of HC. Urine NTP assay measurements of AD with a Clinical Dementia Rate (CDR) of 0.5 (n = 10, 24.2 ± 5.9 μg/mL, P = .063) or of 1.0 (n = 24, 30.1 ± 10.9 μg/mL, P = .000) were significantly higher than in HC. However, the AD patients with CDR of 2.0 (n = 9, 23.1 ± 7.3 μg/mL, P = .136) were not significant.
CONCLUSION: Urine NTP could be used as a safe and promising biochemical marker of early AD.
Young Chul Youn; Kun-Woo Park; Seol-Heui Han; SangYun Kim
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2010-10-02
Journal Detail:
Title:  Journal of the American Medical Directors Association     Volume:  12     ISSN:  1538-9375     ISO Abbreviation:  J Am Med Dir Assoc     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-25     Completed Date:  2011-09-30     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  100893243     Medline TA:  J Am Med Dir Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.
Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea.
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MeSH Terms
Alzheimer Disease / diagnosis*
Biological Markers / urine
Early Diagnosis
Enzyme-Linked Immunosorbent Assay
Middle Aged
Nerve Tissue Proteins / urine*
Prospective Studies
United States
Reg. No./Substance:
0/AD7c-NTP protein, human; 0/Biological Markers; 0/Nerve Tissue Proteins
Comment In:
J Urol. 2012 Sep;188(3):836   [PMID:  22883770 ]

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