Document Detail

Urine biomarkers predict acute kidney injury in newborns.
MedLine Citation:
PMID:  22424940     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify urine biomarkers predictive of acute kidney injury (AKI) in infants admitted to level 2 and 3 neonatal intensive care units with birth weight >2000 g and 5-minute Apgar score ≤ 7.
STUDY DESIGN: A nested case-control study was performed comparing 8 candidate urine AKI biomarkers in infants with AKI (defined as a rise in serum creatinine of at least 0.3 mg/dL or a serum creatinine elevation ≥ 1.7 mg/dL persisting for 3 days) and 24 infants from the described cohort without AKI. Urine was analyzed for neutrophil gelatinase-associated lipocalin, osteopontin, cystatin C, albumin, β(2) microglobulin, epithelial growth factor, uromodulin (UMOD), and kidney injury molecule 1.
RESULTS: Compared with the infants without AKI, those with AKI had higher levels of urine cystatin C (1123 pg/mL [95% CI, 272-4635 pg/mL] vs 90 pg/mL [95% CI, 39-205 pg/mL]; P < .004; area under the receiver operating characteristic curve [AUC] = 0.82), lower levels of UMOD (11.0 pg/mL [95% CI, 5.7-21.4 pg/mL] vs 26.2 pg/mL [95% CI, 17.4-39.4 pg/mL]; P < .03; AUC = 0.77), and lower levels of epithelial growth factor (6.7 pg/mL [95% CI, 4.0-11.3 pg/mL] vs 17.4 pg/mL [95% CI, 12.7-23.8 pg/mL; P = .003; AUC = 0.82). Although the differences were not statistically significant, levels of urine neutrophil-associated gelatinase lipocalin, kidney injury molecule 1, and osteopontin trended higher in infants with AKI.
CONCLUSION: Urinary biomarkers can predict AKI in neonates admitted to level 2 and 3 neonatal intensive care units.
David J Askenazi; Rajesh Koralkar; Hayden E Hundley; Angela Montesanti; Pushkar Parwar; Srdjan Sonjara; Namasivayam Ambalavanan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-16
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-02     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-5.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Acute Kidney Injury / diagnosis*
Acute-Phase Proteins / urine
Biological Markers / blood,  urine*
Case-Control Studies
Creatinine / blood
Cystatin C / urine
Epidermal Growth Factor / urine
Infant, Newborn
Lipocalins / urine
Membrane Glycoproteins / urine
Osteopontin / urine
Predictive Value of Tests
Proto-Oncogene Proteins / urine
Receptors, Virus
Uromodulin / urine
Grant Support
L30 DK089619-01/DK/NIDDK NIH HHS; P30 DK079337/DK/NIDDK NIH HHS; P30 DK079337-04/DK/NIDDK NIH HHS; P30 DK079337-04S1/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Cystatin C; 0/HAVCR1 protein, human; 0/LCN2 protein, human; 0/Lipocalins; 0/Membrane Glycoproteins; 0/Proto-Oncogene Proteins; 0/Receptors, Virus; 0/Uromodulin; 106441-73-0/Osteopontin; 62229-50-9/Epidermal Growth Factor; AYI8EX34EU/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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