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Urinary type IV collagen as a predictor for the incidence of microalbuminuria in young patients with Type 1 diabetes.
MedLine Citation:
PMID:  24103009     Owner:  NLM     Status:  Publisher    
AIMS: To clarify whether urinary type IV collagen:creatinine ratio is a predictor for the incidence of microalbuminuria in patients with Type 1 diabetes.
METHODS: A longitudinal observational cohort study was conducted; the subjects included normoalbuminuric patients diagnosed with Type 1 diabetes before the age of 30 years and who were less than 40 years old at the start of the observation. In total, 225 patients were enrolled (age, mean ± sd: 25 ± 5 years; male: 32.9%). The endpoint was the incidence of microalbuminuria, defined as urinary albumin:creatinine ratio ≥ 30 mg/g Cr and < 300 mg/g Cr. Patients were divided into two groups based on the median of urinary type IV collagen:creatinine ratio levels.
RESULTS: During the median follow-up period of 8.8 years (range 1.0-12.8 years), 13 patients with high urinary type IV collagen:creatinine ratio progressed to microalbuminuria. Meanwhile, only one patient with low urinary type IV collagen:creatinine ratio reached the endpoint. Kaplan-Meier estimates for the time to reach the endpoint were significantly faster for patients with a high ratio than for those with a low ratio (log-rank test, P < 0.001). In the multivariate Cox hazard analysis, the hazard ratio for patients with high vs. low urinary type IV collagen:creatinine ratio was 13.5 (95% CI 1.59-115.02, P = 0.017). When urinary type IV collagen:creatinine ratio was treated as a continuous variable, logarithmically transformed urinary type IV collagen:creatinine ratio, but not baseline albumin:creatinine ratio, was independently associated with reaching the endpoint (hazard ratio 19.23, 95% CI 1.53-242.30, P = 0.022).
CONCLUSIONS: Urinary type IV collagen may be an important predictor for the incidence of microalbuminuria in young patients with Type 1 diabetes. This article is protected by copyright. All rights reserved.
M Morita; K Hanai; Y Uchigata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-16
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  -     ISSN:  1464-5491     ISO Abbreviation:  Diabet. Med.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo; Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane, Japan.
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