| Urinary type II collagen C-terminal peptide is associated with synovitis and predicts structural bone loss in very early inflammatory arthritis. | |
| | |
MedLine Citation:
|
PMID: 20980286 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: In rheumatoid arthritis, high levels of the cartilage turnover biomarker C-terminal cross-linking telopeptide of type II collagen (CTX-II) predict an increased risk of radiological progression. In very early inflammatory arthritis erosions are uncommon, therefore CTX-II requires validation against early markers of inflammatory arthritis such as power Doppler ultrasound (PDUS) synovitis and bone mineral density (BMD) loss. METHODS: In 50 subjects with 12 weeks or less of inflammatory hand symptoms, urinary CTX-II and PDUS were performed at baseline and hand BMD at baseline and 12 months. CTX-II data were log transformed to a normal distribution. Associations between variables were examined using Pearson's r/Spearman's ρ correlations. RESULTS: The mean 12- month change in BMD was -0.0068 g/cm² and the geometric mean for baseline CTX-II/creatinine was 245.89 ng/mmol. Log-transformed baseline CTX-II showed a substantive negative association with change in average BMD over 12 months, controlling for baseline BMD and erythrocyte sedimentation rate (r=-0.359, p=0.044). The median total PDUS score was 3.0 and baseline CTX-II was significantly associated with baseline total PDUS (Spearman's ρ=0.482, p=0.002). CONCLUSION: Urinary CTX-II correlates with PDUS synovitis and hand BMD reduction very early in the course of inflammatory arthritis, suggesting that CTX-II has potential as a biomarker in very early inflammatory arthritis. |
| | |
Authors:
|
J E Freeston; P Garnero; R J Wakefield; E M A Hensor; P G Conaghan; P Emery |
Related Documents
:
|
2339626 - The long-term treatment of steroid osteoporosis with fluoride. 11576376 - Differential effects of growth hormone therapy in malnourished hemodialysis patients. 23075426 - Potential impact of propofol immediately after motor vehicle accident on later symptoms... 2168586 - Long-term effects of dietary calcium on risk markers for colon cancer in patients with ... 10569556 - Tamoxifen versus placebo in the treatment of peyronie's disease. 6284396 - Treatment of vincristine-induced ileus with sincalide, a cholecystokinin analog. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 70 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
|
Languages: eng Pagination: 331-3 Citation Subset: IM |
Affiliation:
|
Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizum...
Next Document: Changes in hip fracture rate before and after total knee replacement due to osteoarthritis: a popula...