Document Detail

Urinary type II collagen C-terminal peptide is associated with synovitis and predicts structural bone loss in very early inflammatory arthritis.
MedLine Citation:
PMID:  20980286     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In rheumatoid arthritis, high levels of the cartilage turnover biomarker C-terminal cross-linking telopeptide of type II collagen (CTX-II) predict an increased risk of radiological progression. In very early inflammatory arthritis erosions are uncommon, therefore CTX-II requires validation against early markers of inflammatory arthritis such as power Doppler ultrasound (PDUS) synovitis and bone mineral density (BMD) loss.
METHODS: In 50 subjects with 12 weeks or less of inflammatory hand symptoms, urinary CTX-II and PDUS were performed at baseline and hand BMD at baseline and 12 months. CTX-II data were log transformed to a normal distribution. Associations between variables were examined using Pearson's r/Spearman's ρ correlations.
RESULTS: The mean 12- month change in BMD was -0.0068 g/cm² and the geometric mean for baseline CTX-II/creatinine was 245.89 ng/mmol. Log-transformed baseline CTX-II showed a substantive negative association with change in average BMD over 12 months, controlling for baseline BMD and erythrocyte sedimentation rate (r=-0.359, p=0.044). The median total PDUS score was 3.0 and baseline CTX-II was significantly associated with baseline total PDUS (Spearman's ρ=0.482, p=0.002).
CONCLUSION: Urinary CTX-II correlates with PDUS synovitis and hand BMD reduction very early in the course of inflammatory arthritis, suggesting that CTX-II has potential as a biomarker in very early inflammatory arthritis.
J E Freeston; P Garnero; R J Wakefield; E M A Hensor; P G Conaghan; P Emery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-10-26
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  70     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-02-17     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  IM    
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MeSH Terms
Absorptiometry, Photon
Arthritis, Rheumatoid / complications,  diagnosis*,  physiopathology
Biological Markers / urine
Bone Density / physiology
Collagen Type II / urine*
Disease Progression
Early Diagnosis
Follow-Up Studies
Hand Joints / physiopathology
Middle Aged
Peptide Fragments / urine*
Synovitis / complications,  diagnosis*,  physiopathology,  urine
Grant Support
18475//Arthritis Research UK
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type II; 0/Peptide Fragments; 0/collagen II C-telopeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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