Document Detail

Urinary tumor necrosis factor levels in primary glomerulopathies.
MedLine Citation:
PMID:  8190181     Owner:  NLM     Status:  MEDLINE    
In the present study, urinary tumor necrosis factor-alpha (TNF) levels in nonproliferative glomerulopathies [minimal change disease (n = 4), focal glomerulosclerosis (n = 4), membranous glomerulonephritis (GN) (n = 1), and in patients with chronic glomerulopathies (n = 4)] were compared to proliferative ones [a rapidly progressive GN patient and 8 patients with mesangial proliferative GN and membranoproliferative GN (MPGN) who had clinically active disease]. The mean urine TNF levels of the proliferative group were significantly higher than both the nonproliferative GN and 4 controls, whereas the mean value of the nonproliferative group was not significantly different than the controls. The urine TNF levels in 4 MPGN patients with chronic disease and in 2 who entered remission were also very low. In the patients with active renal disease and cellular proliferation there were significant correlations between the urinary TNF levels and both proteinuria and the clinical activity scores. We suggest that in human proliferative glomerulopathies TNF may be implicated in the glomerular inflammation.
S Ozen; U Saatci; K Tinaztepe; A Bakkaloglu; A Barut
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  66     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1994  
Date Detail:
Created Date:  1994-06-22     Completed Date:  1994-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  IM    
Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Cell Division / physiology
Child, Preschool
Glomerular Mesangium / cytology
Glomerulonephritis / pathology,  urine*
Glomerulonephritis, Membranoproliferative / pathology,  urine
Glomerulonephritis, Membranous / pathology,  urine
Glomerulosclerosis, Focal Segmental / pathology,  urine
Nephrosis, Lipoid / pathology,  urine
Reference Values
Tumor Necrosis Factor-alpha / urine*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

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