Document Detail

Urinary tract infections in older women: a clinical review.
MedLine Citation:
PMID:  24570248     Owner:  NLM     Status:  MEDLINE    
IMPORTANCE: Asymptomatic bacteriuria and symptomatic urinary tract infections (UTIs) in older women are commonly encountered in outpatient practice.
OBJECTIVE: To review management of asymptomatic bacteriuria and symptomatic UTI and review prevention of recurrent UTIs in older community-dwelling women.
EVIDENCE REVIEW: A search of Ovid (Medline, PsycINFO, Embase) for English-language human studies conducted among adults aged 65 years and older and published in peer-reviewed journals from 1946 to November 20, 2013.
RESULTS: The clinical spectrum of UTIs ranges from asymptomatic bacteriuria, to symptomatic and recurrent UTIs, to sepsis associated with UTI requiring hospitalization. Recent evidence helps differentiate asymptomatic bacteriuria from symptomatic UTI. Asymptomatic bacteriuria is transient in older women, often resolves without any treatment, and is not associated with morbidity or mortality. The diagnosis of symptomatic UTI is made when a patient has both clinical features and laboratory evidence of a urinary infection. Absent other causes, patients presenting with any 2 of the following meet the clinical diagnostic criteria for symptomatic UTI: fever, worsened urinary urgency or frequency, acute dysuria, suprapubic tenderness, or costovertebral angle pain or tenderness. A positive urine culture (≥105 CFU/mL) with no more than 2 uropathogens and pyuria confirms the diagnosis of UTI. Risk factors for recurrent symptomatic UTI include diabetes, functional disability, recent sexual intercourse, prior history of urogynecologic surgery, urinary retention, and urinary incontinence. Testing for UTI is easily performed in the clinic using dipstick tests. When there is a low pretest probability of UTI, a negative dipstick result for leukocyte esterase and nitrites excludes infection. Antibiotics are selected by identifying the uropathogen, knowing local resistance rates, and considering adverse effect profiles. Chronic suppressive antibiotics for 6 to 12 months and vaginal estrogen therapy effectively reduce symptomatic UTI episodes and should be considered in patients with recurrent UTIs.
CONCLUSIONS AND RELEVANCE: Establishing a diagnosis of symptomatic UTI in older women requires careful clinical evaluation with possible laboratory assessment using urinalysis and urine culture. Asymptomatic bacteriuria should be differentiated from symptomatic UTI. Asymptomatic bacteriuria in older women should not be treated.
Lona Mody; Manisha Juthani-Mehta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  JAMA     Volume:  311     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-02-26     Completed Date:  2014-03-03     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-54     Citation Subset:  AIM; IM    
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MeSH Terms
Bacteriuria / diagnosis*,  drug therapy,  prevention & control
Urinary Tract Infections / complications,  diagnosis*,  drug therapy,  prevention & control
Grant Support
1R01AG041153/AG/NIA NIH HHS; 5K23A028691//PHS HHS; P30 AG021342/AG/NIA NIH HHS; P30 AG021342/AG/NIA NIH HHS; P30 AG024824/AG/NIA NIH HHS; P30 AG024824/AG/NIA NIH HHS; R01 AG032298/AG/NIA NIH HHS; R01 AG032298/AG/NIA NIH HHS; R01 AG041780/AG/NIA NIH HHS; R01 AG41780/AG/NIA NIH HHS; R18 HS019979/HS/AHRQ HHS

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