| Urinary tract infections in infants: comparison between those with conjugated vs unconjugated hyperbilirubinaemia. | |
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MedLine Citation:
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PMID: 16297302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim was to investigate conjugated and unconjugated hyperbilirubinaemia in association with urinary tract infection (UTI) in young infants. METHODS: Fifty infants aged <3 mths who developed prolonged jaundice among 2128 infants with UTI from 1984 to 2004 were enrolled retrospectively. They were divided into conjugated (n=22) and unconjugated (n=28) hyperbilirubinaemia groups and the clinical variables between the two were compared. RESULTS: Compared with the unconjugated group, the conjugated hyperbilirubinaemia group had statistically significantly lower haemoglobin (1.57 vs 1.80 micromol/L), higher aspartate aminotransferase (96 vs 32.5 U/L) and alanine aminotransferase (81.5 vs 16 U/L), were older on admission (48.0 vs 32.5 days), had a longer duration of jaundice before treatment (43.5 vs 30 days) and a higher incidence of E. coli infections (19/22 vs 15/28). The direct/total bilirubin ratio was linearly correlated with duration of jaundice before treatment (p=0.004). The most significant cut-off value for the duration of jaundice vis-à-vis the type of jaundice was 38 days (p=0.007). Patients who on presentation had had jaundice for >44 days (p=0.007) were unlikely to have unconjugated hyperbilirubinaemia. CONCLUSIONS: Infants with UTI may present with unconjugated hyperbilirubinaemia in the early stage. After 6 weeks, it is always conjugated hyperbilirubinaemia and is frequently associated with anaemia, elevated hepatic aminotransferases and E. coli infections. |
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Authors:
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Hung-Chang Lee; Shiuh-Bin Fang; Chun-Yan Yeung; Jeng-Daw Tsai |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of tropical paediatrics Volume: 25 ISSN: 0272-4936 ISO Abbreviation: Ann Trop Paediatr Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-21 Completed Date: 2006-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8210625 Medline TA: Ann Trop Paediatr Country: England |
Other Details:
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Languages: eng Pagination: 277-82 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Mackay Memorial Hospital, Taiwan; Department of Paediatrics, Taipei Medical Uinversity, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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blood Female Humans Hyperbilirubinemia / blood, complications*, microbiology Hyperbilirubinemia, Neonatal / blood, complications, microbiology Infant Infant, Newborn Jaundice / blood, complications, microbiology Jaundice, Neonatal / blood, complications, microbiology Male Retrospective Studies Time Factors Transaminases / blood Urinary Tract Infections / blood, complications*, microbiology |
| Chemical | |
Reg. No./Substance:
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635-65-4/Bilirubin; EC 2.6.1.-/Transaminases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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