Document Detail

Urinary tract infections in infants: comparison between those with conjugated vs unconjugated hyperbilirubinaemia.
MedLine Citation:
PMID:  16297302     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim was to investigate conjugated and unconjugated hyperbilirubinaemia in association with urinary tract infection (UTI) in young infants. METHODS: Fifty infants aged <3 mths who developed prolonged jaundice among 2128 infants with UTI from 1984 to 2004 were enrolled retrospectively. They were divided into conjugated (n=22) and unconjugated (n=28) hyperbilirubinaemia groups and the clinical variables between the two were compared. RESULTS: Compared with the unconjugated group, the conjugated hyperbilirubinaemia group had statistically significantly lower haemoglobin (1.57 vs 1.80 micromol/L), higher aspartate aminotransferase (96 vs 32.5 U/L) and alanine aminotransferase (81.5 vs 16 U/L), were older on admission (48.0 vs 32.5 days), had a longer duration of jaundice before treatment (43.5 vs 30 days) and a higher incidence of E. coli infections (19/22 vs 15/28). The direct/total bilirubin ratio was linearly correlated with duration of jaundice before treatment (p=0.004). The most significant cut-off value for the duration of jaundice vis-à-vis the type of jaundice was 38 days (p=0.007). Patients who on presentation had had jaundice for >44 days (p=0.007) were unlikely to have unconjugated hyperbilirubinaemia. CONCLUSIONS: Infants with UTI may present with unconjugated hyperbilirubinaemia in the early stage. After 6 weeks, it is always conjugated hyperbilirubinaemia and is frequently associated with anaemia, elevated hepatic aminotransferases and E. coli infections.
Hung-Chang Lee; Shiuh-Bin Fang; Chun-Yan Yeung; Jeng-Daw Tsai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  25     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-21     Completed Date:  2006-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Department of Paediatrics, Mackay Memorial Hospital, Taiwan; Department of Paediatrics, Taipei Medical Uinversity, Taiwan.
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MeSH Terms
Bilirubin / blood
Hyperbilirubinemia / blood,  complications*,  microbiology
Hyperbilirubinemia, Neonatal / blood,  complications,  microbiology
Infant, Newborn
Jaundice / blood,  complications,  microbiology
Jaundice, Neonatal / blood,  complications,  microbiology
Retrospective Studies
Time Factors
Transaminases / blood
Urinary Tract Infections / blood,  complications*,  microbiology
Reg. No./Substance:
635-65-4/Bilirubin; EC 2.6.1.-/Transaminases

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