Document Detail

Urinary tract infections in African infants.
MedLine Citation:
PMID:  15364303     Owner:  NLM     Status:  MEDLINE    
Urinary tract infection (UTI) causes significant illness in the first 2 years of life. The diagnosis in most developing countries is often overlooked due to the tedious nature of obtaining urine from these young ones who would not void voluntarily. Misdiagnosis very often lead to avoidable ill health and long-term renal damage. There is a need to diagnose UTI in febrile infants to alert clinicians. A prospective study of febrile infants aged up to 12 months on admission was undertaken in a 6-months period. Urine specimen was obtained by supra pubic aspiration and investigated. Out of 150 urine samples screened for UTI, 45 (30%) had positive bacterial growth. Escherichia coli (32%) and Proteus sp. (22%) formed more than 50% of the total isolates. The Gram positive bacteria isolated was Staphylococcus aureus representing 11%. All isolates were susceptible to cefuroxime and resistant to ampicillin. Susceptibility to amoxicillin/clavulanic acid was 77.8% and to nitrofurantoin was 67%. Only 11.1% of isolates were susceptible to cotrimoxazole. These results indicate that UTI is a common cause of pyrexia in infants requiring admission. These infants when clinically diagnosed as having UTI are treated with ampicillin and cotrimoxazole. They do not have the benefit of further investigation for renal abnormalities and subsequent antibiotic prophylactics to prevent recurrent infection, which could result in renal scarring and its associated problems later.
Ohene Adjei; Charles Opoku
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  24 Suppl 1     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S32-4     Citation Subset:  IM    
Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Bacterial Infections / complications*,  microbiology
Enterobacteriaceae / drug effects,  isolation & purification
Fever / etiology*
Infant, Newborn
Microbial Sensitivity Tests
Prospective Studies
Staphylococcus aureus / drug effects,  isolation & purification
Urinary Tract Infections / complications*,  microbiology
Reg. No./Substance:
0/Anti-Bacterial Agents

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