Document Detail


Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review.
MedLine Citation:
PMID:  18401538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the prevalence of urinary tract infection (UTI) after pelvic floor operations for non-malignant etiology and the effectiveness of antibiotic prophylaxis. This was made possible by a review of the evidence from relevant randomized controlled trials (RCTs). Nineteen out of 879 initially identified studies met the criteria for inclusion in our review. Four RCTs compared an antibiotic prophylactic regimen with placebo, 11 two different prophylactic antibiotic regimens, and four had three different treatment arms. Among placebo recipients undergoing pelvic floor surgery, 10-64% developed UTI. In contrast, UTI after pelvic floor gynecological surgery occurred in 0-15% of the patients who received cephalosporins as antibiotic prophylaxis; the likelihood for postoperative UTI was higher for patients receiving cotrimoxazole (28%), ampicillin/sulbactam (13.6%), metronidazole plus ampicillin (20%), metronidazole (10-22.7%), or ciprofloxacin (27.2%). The use of a cephalosporin as perioperative antimicrobial prophylaxis is the optimal regimen in preventing UTIs after pelvic floor surgery.
Authors:
Matthew E Falagas; Stavros Athanasiou; Christos Iavazzo; Theodoros Tokas; Aris Antsaklis
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2008-04-10
Journal Detail:
Title:  International urogynecology journal and pelvic floor dysfunction     Volume:  19     ISSN:  -     ISO Abbreviation:  Int Urogynecol J Pelvic Floor Dysfunct     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-12-17     Revised Date:  2011-08-18    
Medline Journal Info:
Nlm Unique ID:  9514583     Medline TA:  Int Urogynecol J Pelvic Floor Dysfunct     Country:  England    
Other Details:
Languages:  eng     Pagination:  1165-72     Citation Subset:  IM    
Affiliation:
Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, Marousi, 151 23 Athens, Greece. m.falagas@aibs.gr
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MeSH Terms
Descriptor/Qualifier:
Antibiotic Prophylaxis* / statistics & numerical data
Cephalosporins / therapeutic use
Female
Gynecologic Surgical Procedures / adverse effects*
Humans
Pelvic Floor
Postoperative Complications / epidemiology
Prevalence
Randomized Controlled Trials as Topic
Urinary Tract Infections / epidemiology*
Chemical
Reg. No./Substance:
0/Cephalosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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