Document Detail

Urinary tract infection caused by carbapenem-resistant K. pneumoniae and P. aeruginosa.
MedLine Citation:
PMID:  22568274     Owner:  NLM     Status:  In-Process    
There has been an increase in recent years of antimicrobial resistance of Gram negative bacilli (GNB). Carbapenems, the mainstay for the treatment of multidrug resistant GNB infections, are no longer always effective leaving treatment options limited. We present the case of patient with recurrent, complicated urinary tract infections. The current episode was caused by carbapenem-resistant K. pneumoniae and P. aeruginosa and carbapenem-susceptible, but MDR E. cloacae. Resistance to carbapenems of K. pneumoniae was conferred by the production of the class B metallo-beta-lactamase, VIM1. Infection control measures were implemented and following a 2-week course of treatment with colistin, the infection resolved and the patient was discharged. We discuss the changes in the epidemiology, the mechanisms involved and the means of detecting carbapenem resistance in GNB. We would also like to stress the role of infection control measures in limiting patient-to-patient spread of MDR organisms which, are of paramount importance in cases when few treatment options are left available.
Ioana D Olaru; Mona Popoiu; J Breuil; Victoria Aramă; Adriana Hristea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  49     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2011  
Date Detail:
Created Date:  2012-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Prof. Dr. Matei Balş National Institute of Infectious Diseases, Bucharest, Romania.
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