Document Detail

Urinary response to an oxalic acid load is influenced by the timing of calcium loading in rats.
MedLine Citation:
PMID:  16217387     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Dietary intake of calcium or dairy products has been shown to decrease urinary oxalate excretion by limiting its intestinal absorption. However, not enough attention has been given to whether there is any benefit from altering the schedule of ingesting calcium and oxalate. Therefore, we investigated the effects of changes in the timing of calcium and oxalate loading on urinary oxalate excretion. MATERIALS AND METHODS: Male Wistar rats weighing 180 to 200 gm were fasted and randomized into several groups. They were then administered normal saline or oxalic acid with or without calcium or milk. Calcium or milk was given immediately, or 5, 10, 15 or 30 minutes before or after the oxalate load. All treatments were given via gastrostomy. Urine samples were collected by bladder puncture just before administration and at hourly intervals up to 5 hours afterward. Urinary oxalate was measured by capillary electrophoresis. RESULTS: Urinary oxalate increased after the administration of oxalate alone, while it decreased when oxalate was combined with calcium or milk. Urinary oxalate showed a smaller increment when calcium or milk was given before than after oxalate loading, and it was much smaller when calcium or milk was given immediately before oxalate. CONCLUSIONS: Prior calcium loading appears to have a positive influence on decreasing oxalic acid absorption from the intestinal tract. Therefore, calcium or dairy products should always be ingested before a meal rich in oxalate to prevent oxalate absorption and decrease urinary oxalate excretion.
Rayhan Zubair Hossain; Yoshihide Ogawa; Makoto Morozumi; Sanehiro Hokama; Atsushi Uchida; Kimio Sugaya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  174     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2005-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2027-31     Citation Subset:  AIM; IM    
Division of Urology, Department of Organ-Oriented Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
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MeSH Terms
Analysis of Variance
Calcium / administration & dosage,  urine
Calcium Oxalate / metabolism,  urine*
Dietary Supplements
Disease Models, Animal
Intestinal Absorption / physiology*
Oxalic Acid / pharmacokinetics*,  pharmacology
Random Allocation
Rats, Wistar
Reference Values
Sensitivity and Specificity
Time Factors
Reg. No./Substance:
144-62-7/Oxalic Acid; 25454-23-3/Calcium Oxalate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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