Document Detail


Urinary proteins in Sprague-Dawley rats with chronic progressive nephrosis.
MedLine Citation:
PMID:  54454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By means of polyacrylamide concentration and electrophoresis on cellulose acetate strips, protein fractions have been determined in the urine of male Sprague-Dawley rats from 6 1/2-28 mo of age. An increasing percentage of albumin was expressed in the albumin/globulin ratios of 0.72, in a group of rats excreting a mean concentration of 1.91 mg/ml of protein in the urine, and 2.24 in a group of rats excreting, on the average, 17.62 mg/ml. A relative decrease in globulin, particularly of the alpha2 fraction, was shown. From a statistical model based on the regression parameters for 24-hr protein excretion and urine protein concentration, it was estimated that the doubling time for protein excretion was 3.2-3.69 mo. This interval is roughly one-half that reported for the Wistar rat.
Authors:
R N Weaver; J E Gray; J R Schultz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  25     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  705-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Albuminuria / veterinary
Alpha-Globulins / urine
Animals
Male
Nephrosis / urine,  veterinary*
Proteinuria / veterinary*
Rats*
Rodent Diseases / urine*
gamma-Globulins / urine
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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