| Urinary protein excretion patterns in reactive (secondary) systemic amyloidosis. | |
| | |
MedLine Citation:
|
PMID: 3148996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The urinary excretion of immunoglobulin light chains kappa and lambda, immunoglobulin G, transferrin, and beta-2-microglobulin was studied in 21 patients with nonimmunoglobulin-related amyloid nephropathy (secondary, type AA) associated with rheumatic disease and in 39 patients with glomerulopathy of nonamyloid origin, as well as in 22 patients with rheumatic disease without signs of nephropathy and in 15 healthy subjects. Patients with amyloidosis were found to have a higher ratio of excreted lambda/kappa light chains than patients with diabetic nephropathy or chronic glomerulonephritis. The increased lambda/kappa ratio was not dependent on the grade of proteinuria and was evident in patients with mild as well as heavy proteinuria. The ratio of lambda/kappa light chains in serum of patients with amyloidosis did not differ from that in healthy controls. The results suggest that amyloid deposition in the kidneys is associated with a selective alternation of the immunoglobulin light chain excretion in the urine. |
| | |
Authors:
|
A M Teppo; C P Maury |
Related Documents
:
|
21811806 - Second-half-of-the-day headache as a manifestation of spontaneous csf leak. 7611186 - The pathologic spectrum of pulmonary lesions in patients with anti-neutrophil cytoplasm... 19646346 - Glycosylation of proteinase 3 (pr3) is not required for its reactivity with antineutrop... 16060126 - Secondary membranous nephropathy--one center experience. 9358526 - Effect of dialysis modality and membrane transport characteristics on dialysate protein... 11532406 - Free fluid on abdominal computed tomography without solid organ injury after blunt abdo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Rheumatology international Volume: 8 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 1988 |
Date Detail:
|
Created Date: 1989-05-03 Completed Date: 1989-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 213-7 Citation Subset: IM |
Affiliation:
|
Fourth Department of Medicine, University of Helsinki, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amyloidosis
/
urine* Humans Immunoglobulin Light Chains / urine Kidney Diseases / urine* Proteinuria / etiology* Transferrin / urine beta 2-Microglobulin / urine |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin Light Chains; 0/beta 2-Microglobulin; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-Sm and anti-DNA antibodies in paired serum and synovial fluid samples from patients with SLE.
Next Document: Occurrence of a mu-chain idiotope in two human monoclonal RF which also share a kappa-chain idiotope...