Document Detail


Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome.
MedLine Citation:
PMID:  15269099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral lymphocytes from healthy pregnant women secrete a mediator protein named the progesterone-induced blocking factor (PIBF) that exerts an immunomodulatory function and contributes to the maintenance of pregnancy in mice. The gene coding for PIBF mRNA has been cloned and sequenced, and now the recombinant human protein is available. The aim of this study was to develop an ELISA test for determining PIBF concentrations in biological samples of pregnant women. We determined urinary PIBF concentrations of 86 healthy nonpregnant individuals and from almost 500 pregnant women by ELISA. During normal pregnancy, the concentration of PIBF continuously increased until the 37th gestational week and was followed by a sharp decrease after the 41st week of gestation. In pathological pregnancies, urinary PIBF levels failed to increase. The onset of labor was predictable on the basis of this test, whether it was term or preterm delivery. In urine of patients with preeclampsia, PIBF concentrations were significantly lower than in normal pregnancy and showed a correlation with the number of symptoms presented. These data, in line with previous in vivo findings, suggest that PIBF production is a characteristic feature of normal pregnancy, and determination of PIBF concentration in urine might be of use for the diagnosis of threatened premature pregnancy termination.
Authors:
Beáta Polgár; Eszter Nagy; Eva Mikó; Péter Varga; Júlia Szekeres-Barthó
Related Documents :
15269099 - Urinary progesterone-induced blocking factor concentration is related to pregnancy outc...
21285999 - Oocyte donation: a risk factor for pregnancy-induced hypertension: a meta-analysis and ...
21278499 - Intrauterine resuscitation during labor.
23719249 - Placenta accreta in a patient with a history of uterine artery embolization for postpar...
21122609 - Fetal movements in the third trimester--important information about wellbeing of the fe...
21450029 - Two cases of angular pregnancy complicated by preterm labor and placental abruption at ...
2673609 - Observations of biophysical activities in the normal fetus.
18266939 - Cytokine networks and the regulation of uterine function in pregnancy and parturition.
6226459 - Prenatal diagnosis of tay-sachs disease with heat-labile beta-hexosaminidase b.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-07-21
Journal Detail:
Title:  Biology of reproduction     Volume:  71     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-21     Completed Date:  2005-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1699-705     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology and Immunology, Medical School, Pécs University, 12 Szigeti Str. H-7624 Pécs, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology,  urine
Adolescent
Adult
Case-Control Studies
Enzyme-Linked Immunosorbent Assay / methods*,  standards
Female
Humans
Osmolar Concentration
Pre-Eclampsia / urine
Pregnancy / urine*
Pregnancy Complications / urine
Pregnancy Outcome*
Pregnancy Proteins / urine*
Protein Isoforms / urine
Reproducibility of Results
Risk Factors
Suppressor Factors, Immunologic
Chemical
Reg. No./Substance:
0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Protein Isoforms; 0/Suppressor Factors, Immunologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Real-time relationships in intraluteal release among Prostaglandin F2alpha, endothelin-1, and angiot...
Next Document:  Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis.