Document Detail

Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome.
MedLine Citation:
PMID:  15269099     Owner:  NLM     Status:  MEDLINE    
Peripheral lymphocytes from healthy pregnant women secrete a mediator protein named the progesterone-induced blocking factor (PIBF) that exerts an immunomodulatory function and contributes to the maintenance of pregnancy in mice. The gene coding for PIBF mRNA has been cloned and sequenced, and now the recombinant human protein is available. The aim of this study was to develop an ELISA test for determining PIBF concentrations in biological samples of pregnant women. We determined urinary PIBF concentrations of 86 healthy nonpregnant individuals and from almost 500 pregnant women by ELISA. During normal pregnancy, the concentration of PIBF continuously increased until the 37th gestational week and was followed by a sharp decrease after the 41st week of gestation. In pathological pregnancies, urinary PIBF levels failed to increase. The onset of labor was predictable on the basis of this test, whether it was term or preterm delivery. In urine of patients with preeclampsia, PIBF concentrations were significantly lower than in normal pregnancy and showed a correlation with the number of symptoms presented. These data, in line with previous in vivo findings, suggest that PIBF production is a characteristic feature of normal pregnancy, and determination of PIBF concentration in urine might be of use for the diagnosis of threatened premature pregnancy termination.
Beáta Polgár; Eszter Nagy; Eva Mikó; Péter Varga; Júlia Szekeres-Barthó
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-07-21
Journal Detail:
Title:  Biology of reproduction     Volume:  71     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-21     Completed Date:  2005-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1699-705     Citation Subset:  IM    
Department of Medical Microbiology and Immunology, Medical School, Pécs University, 12 Szigeti Str. H-7624 Pécs, Hungary.
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MeSH Terms
Abortion, Spontaneous / etiology,  urine
Case-Control Studies
Enzyme-Linked Immunosorbent Assay / methods*,  standards
Osmolar Concentration
Pre-Eclampsia / urine
Pregnancy / urine*
Pregnancy Complications / urine
Pregnancy Outcome*
Pregnancy Proteins / urine*
Protein Isoforms / urine
Reproducibility of Results
Risk Factors
Suppressor Factors, Immunologic
Reg. No./Substance:
0/PIBF1 protein, human; 0/Pregnancy Proteins; 0/Protein Isoforms; 0/Suppressor Factors, Immunologic

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