Document Detail

Urinary pregnanetriol excretion in hirsutism.
MedLine Citation:
PMID:  199379     Owner:  NLM     Status:  MEDLINE    
Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.
W Van't Hoff; E J Bicknell; P M Horrocks; J A Fleetwood; M Inthuprapa; R Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  80     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / diagnostic use
Hirsutism / urine*
Metyrapone / diagnostic use
Middle Aged
Pregnanetriol / urine*
Time Factors
Reg. No./Substance:
27178-64-9/Pregnanetriol; 54-36-4/Metyrapone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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