Document Detail

Urinary oxalic acid excretion differs after oral loading of rats with various oxalate salts.
MedLine Citation:
PMID:  12534926     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To compare urinary oxalate excretion after the oral administration of oxalic acid, disodium oxalate, or calcium oxalate in rats. METHODS: Male Wistar rats were divided into four groups of six rats each and were intravenously hydrated with normal saline, and then were administered normal saline (control group), 10 mg of oxalic acid, equimolar disodium oxalate, or equimolar calcium oxalate via a gastrostomy. Urine specimens were collected just before administration and at hourly intervals up to 5 h afterwards. The urinary oxalate, calcium, magnesium and phosphorus levels were measured. RESULTS: Urinary oxalate excretion peaked at 1-2 h after administration of oxalic acid or equimolar disodium oxalate, while administration of calcium oxalate only caused a small increase of urinary oxalate excretion. Cumulative urinary oxalate excretion during 5 h was 1.69 +/- 0.10 mg (mean +/- SD; 17%), 1.43 +/- 0.13 mg (13%), and 0.22 +/- 0.03 mg (2%) after the administration of oxalic acid, disodium oxalate, and calcium oxalate, respectively. Urinary calcium excretion showed a decrease in the oxalic acid and disodium oxalate groups, while urinary magnesium or phosphorus excretion did not change significantly. CONCLUSION: The upper gastrointestinal tract seems to be the major site of oxalic acid absorption and only free oxalate is absorbed irrespective of whether it is the sodium salt or not. After binding to calcium in the gut, oxalic acid absorption seems to be inhibited in the presence of calcium and this means that calcium oxalate is poorly absorbed (at least in the upper gastrointestinal tract).
Rayhan Zubair Hossain; Yoshihide Ogawa; Makoto Morozumi; Kimio Sugaya; Tadashi Hatano
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  10     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Department of Urology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
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MeSH Terms
Administration, Oral
Calcium / urine
Calcium Oxalate / administration & dosage,  pharmacokinetics*
Digestive System / metabolism
Intestinal Absorption / physiology
Magnesium / urine
Oxalates / administration & dosage,  urine*
Oxalic Acid / administration & dosage*,  pharmacokinetics*
Phosphorus / urine
Rats, Wistar
Reducing Agents / administration & dosage*
Reference Values
Time Factors
Reg. No./Substance:
0/Oxalates; 0/Reducing Agents; 144-62-7/Oxalic Acid; 25454-23-3/Calcium Oxalate; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7723-14-0/Phosphorus

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