| Urinary oxalic acid excretion differs after oral loading of rats with various oxalate salts. | |
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MedLine Citation:
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PMID: 12534926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To compare urinary oxalate excretion after the oral administration of oxalic acid, disodium oxalate, or calcium oxalate in rats. METHODS: Male Wistar rats were divided into four groups of six rats each and were intravenously hydrated with normal saline, and then were administered normal saline (control group), 10 mg of oxalic acid, equimolar disodium oxalate, or equimolar calcium oxalate via a gastrostomy. Urine specimens were collected just before administration and at hourly intervals up to 5 h afterwards. The urinary oxalate, calcium, magnesium and phosphorus levels were measured. RESULTS: Urinary oxalate excretion peaked at 1-2 h after administration of oxalic acid or equimolar disodium oxalate, while administration of calcium oxalate only caused a small increase of urinary oxalate excretion. Cumulative urinary oxalate excretion during 5 h was 1.69 +/- 0.10 mg (mean +/- SD; 17%), 1.43 +/- 0.13 mg (13%), and 0.22 +/- 0.03 mg (2%) after the administration of oxalic acid, disodium oxalate, and calcium oxalate, respectively. Urinary calcium excretion showed a decrease in the oxalic acid and disodium oxalate groups, while urinary magnesium or phosphorus excretion did not change significantly. CONCLUSION: The upper gastrointestinal tract seems to be the major site of oxalic acid absorption and only free oxalate is absorbed irrespective of whether it is the sodium salt or not. After binding to calcium in the gut, oxalic acid absorption seems to be inhibited in the presence of calcium and this means that calcium oxalate is poorly absorbed (at least in the upper gastrointestinal tract). |
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Authors:
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Rayhan Zubair Hossain; Yoshihide Ogawa; Makoto Morozumi; Kimio Sugaya; Tadashi Hatano |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of urology : official journal of the Japanese Urological Association Volume: 10 ISSN: 0919-8172 ISO Abbreviation: Int. J. Urol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-21 Completed Date: 2003-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9440237 Medline TA: Int J Urol Country: Australia |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Affiliation:
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Department of Urology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. k008744@med.u-ryukyu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Calcium / urine Calcium Oxalate / administration & dosage, pharmacokinetics* Digestive System / metabolism Intestinal Absorption / physiology Magnesium / urine Male Oxalates / administration & dosage, urine* Oxalic Acid / administration & dosage*, pharmacokinetics* Phosphorus / urine Rats Rats, Wistar Reducing Agents / administration & dosage* Reference Values Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Oxalates; 0/Reducing Agents; 144-62-7/Oxalic Acid; 25454-23-3/Calcium Oxalate; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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