Document Detail

Urinary osteocalcin (U-MidOC) and serum pro-C-type natriuretic peptide (S-proCNP) predict linear catch-up growth in infants.
MedLine Citation:
PMID:  22407446     Owner:  NLM     Status:  Publisher    
Preterm (PT) infants are at risk of growth failure despite advanced early care and nutrition. In addition to poor weight gain, also slow postnatal linear growth is associated with adverse neurological outcome. Markers distinguishing infants at risk for impaired catch-up growth are needed. The aim of this longitudinal study was to determine the extent to which postnatal levels of circulating cartilage (S-proCNP) and urinary bone metabolic markers (U-MidOC, U-α-CTX-I and U-β-CTX-I) predict catch-up growth in infancy in 67 PT and 58 full term (FT) infants. PT infants were significantly shorter than FT infants during the first six months of life but no statistically significant difference was seen at the corrected age of 14 months (M14). At the age of three months (M3), S-ProCNP and U-MidOC levels, but not U-α-CTX-I and U-β-CTX-I levels, correlated positively with prospective growth velocity from M3 to M14 (ρ= 0.460, P < 0.001 and ρ= 0.710, P < 0.001, respectively). In predicting slow linear growth (growth velocity at the lowest quartile), the area under the S-ProCNP ROC curve was 0.662 and and that of U-MidOC 0.891. Thus, U-MidOC, and to lesser extent S-ProCNP at M3 are predictors of forthcoming catch-up growth in infancy. © 2012 American Society for Bone and Mineral Research.
Leena Kilpeläinen; Kaisa K Ivaska; Tanja Kuiri-Hänninen; H Kalervo Väänänen; Jens F Rehfeld; Jens P Goetze; Ulla Sankilampi; Leo Dunkel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  -     ISSN:  1523-4681     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Bone and Mineral Research.
Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, FI-70211, Kuopio, Finland.
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