| Urinary oligosaccharide excretion in nephrotic syndrome. | |
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MedLine Citation:
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PMID: 8255672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urinary oligosaccharides from nephrotic syndrome patients were investigated by Bio-Gel P-4 column chromatography and methylation analysis to clarify the electrostatic defects and size barrier defects in the glomerular basement membrane of nephrotic syndrome patients. The levels of urinary oligosaccharides (nmol/mg creatinine) in nephrotic syndrome patients were about 25 times the levels in controls. The ratio of neutral oligosaccharides to sialyl oligosaccharides was about 1:1 in the urine of nephrotic syndrome patients. The levels of neutral oligosaccharides in the urine of nephrotic syndrome patients were about 13 times that of controls. The proportion of trisialylated oligosaccharides in the urine of nephrotic syndrome patients was higher than that in galactosialidosis patients. These findings suggest that electrostatic defects and size barrier defects in the glomerular basement membrane might contribute to the characteristic oligosacchariduria of nephrotic syndrome patients. In addition, the structures of 11 different kinds of oligosaccharides that have not been previously reported were identified in the urine of nephrotic syndrome patients. |
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Authors:
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Y Takahashi; S Omiya; Y Nakamura; N Kondo; T Orii |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 34 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-10 Completed Date: 1994-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 429-34 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Gifu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Age of Onset Biological Markers / urine Carbohydrate Conformation Carbohydrate Metabolism, Inborn Errors / urine Carbohydrate Sequence Child Child, Preschool Chronic Disease Humans Molecular Sequence Data Nephrotic Syndrome / physiopathology, urine* Oligosaccharides / chemistry, isolation & purification, urine* Reference Values Sialic Acids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Oligosaccharides; 0/Sialic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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