Document Detail

Urinary nerve growth factor level is correlated with the severity of neurological impairment in patients with cerebrovascular accident.
MedLine Citation:
PMID:  19338537     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure urinary nerve growth factor (uNGF, essential in nerve growth and regeneration) levels in patients with a cerebrovascular accident (CVA), to determine whether uNGF could be a biomarker for predicting the neurological deficits in CVA, as the level of uNGF increases in patients with idiopathic detrusor overactivity (DO) and incontinence. PATIENTS, SUBJECTS AND METHODS: uNGF levels were measured using an enzyme-linked immunosorbent assay in normal subjects and patients with CVA and different severities of neurological impairment. Total uNGF levels were normalized to the concentration of urinary creatinine (uNGF/Cr). RESULTS: The median (interquartile range) uNGF/Cr levels were significantly higher in patients, at 0.13 (0-1.04), than in normal subjects (undetectable). The uNGF/Cr levels correlated well with the severity of neurological impairment. Patients with none/minimal neurological impairment had no detectable uNGF/Cr level, like the controls. Patients with mild/moderate impairment had levels of 0.27 (0.09-0.8) and with severe impairment level of 1.53 (0.5-3.0) (both P < 0.001), significantly greater than that of none/minimal impairment or controls. However, uNGF/Cr levels were not correlated with age, location of CVA, multiplicity of CVA, duration of CVA, urodynamic findings or the presence of urge urinary incontinence. CONCLUSIONS: The uNGF level is correlated with the severity of neurological impairment in patients with CVA but not with urge symptoms or urodynamic findings, suggesting elevated uNGF might be a result of the neurological lesion rather than lower urinary tract dysfunction in CVA.
Hsin-Tzu Liu; An-Bang Liu; Michael B Chancellor; Hann-Chorng Kuo
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Publication Detail:
Type:  Journal Article     Date:  2009-03-30
Journal Detail:
Title:  BJU international     Volume:  104     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1158-62     Citation Subset:  IM    
Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
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MeSH Terms
Aged, 80 and over
Biological Markers / urine
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Middle Aged
Nerve Growth Factor / urine*
Nervous System Diseases / etiology,  physiopathology,  urine*
Severity of Illness Index
Stroke / etiology,  physiopathology,  urine*
Urinary Bladder, Overactive / etiology,  physiopathology*,  urine
Urinary Incontinence / etiology,  physiopathology*,  urine
Urodynamics / physiology
Reg. No./Substance:
0/Biological Markers; 9061-61-4/Nerve Growth Factor

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