Document Detail


Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.
MedLine Citation:
PMID:  19017700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs).
METHODS: The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed to emissions from asphalt (medium PAH exposure level, n = 26) and coke ovens (high PAH exposure level, n = 28). Levels of Nap and Phe were measured in urine from each subject using head space-solid phase microextraction and gas chromatography-mass spectrometry. Published levels of airborne Nap, Phe and other PAHs in the coke-producing and aluminium industries were also investigated.
RESULTS: In post-shift urine, the highest estimated geometric mean concentrations of Nap and Phe were observed in coke-oven workers (Nap: 2490 ng/l; Phe: 975 ng/l), followed by asphalt workers (Nap: 71.5 ng/l; Phe: 54.3 ng/l), and by diesel-exposed workers (Nap: 17.7 ng/l; Phe: 3.60 ng/l). After subtracting logged background levels of Nap and Phe from the logged post-shift levels of these PAHs in urine, the resulting values (referred to as ln(adjNap) and ln(adjPhe), respectively) were significantly correlated in each group of workers (0.71 < or = Pearson r < or = 0.89), suggesting a common exposure source in each case. Surprisingly, multiple linear regression analysis of ln(adjNap) on ln(adjPhe) showed no significant effect of the source of exposure (coke ovens, asphalt and diesel exhaust) and further suggested that the ratio of urinary Nap/Phe (in natural scale) decreased with increasing exposure levels. These results were corroborated with published data for airborne Nap and Phe in the coke-producing and aluminium industries. The published air measurements also indicated that Nap and Phe levels were proportional to the levels of all combined PAHs in those industries.
CONCLUSION: Levels of Nap and Phe in urine reflect airborne exposures to these compounds and are promising surrogates for occupational exposures to PAH mixtures.
Authors:
J R Sobus; S Waidyanatha; M D McClean; R F Herrick; T J Smith; E Garshick; F Laden; J E Hart; Y Zheng; S M Rappaport
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-11-18
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  66     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-02-27     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Affiliation:
School of Public Health, University of North Carolina,Chapel Hill, North Carolina, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants, Occupational / analysis
Biological Markers / urine
Environmental Monitoring / methods*
Humans
Industry
Inhalation Exposure / analysis
Male
Naphthalenes / analysis,  urine*
Occupational Exposure / analysis*
Phenanthrenes / analysis,  urine*
Polycyclic Hydrocarbons, Aromatic / analysis*
Vehicle Emissions / analysis
Grant Support
ID/Acronym/Agency:
P30ES0002/ES/NIEHS NIH HHS; P30ES10126/ES/NIEHS NIH HHS; P42ES05948/ES/NIEHS NIH HHS; R01 CA090792/CA/NCI NIH HHS; R01 CA090792-05/CA/NCI NIH HHS; R01CA90792/CA/NCI NIH HHS; T32ES07018/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Biological Markers; 0/Naphthalenes; 0/Phenanthrenes; 0/Polycyclic Hydrocarbons, Aromatic; 0/Vehicle Emissions; 2166IN72UN/naphthalene; 448J8E5BST/phenanthrene
Comments/Corrections

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