Document Detail


Urinary mycoestrogens, body size and breast development in New Jersey girls.
MedLine Citation:
PMID:  21975003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Despite extensive research and interest in endocrine disruptors, there are essentially no epidemiologic studies of estrogenic mycotoxins, such as zeranol and zearalenone (ZEA). ZEA mycoestrogens are present in grains and other plant foods through fungal contamination, and in animal products (e.g., meat, eggs, dairy products) through deliberate introduction of zeranol into livestock to enhance meat production, or by indirect contamination of animals through consumption of contaminated feedstuff. Zeranol is banned for use in animal husbandry in the European Union and other countries, but is still widely used in the US. Surprisingly, little is known about the health effects of these mycoestrogens, including their impact on puberty in girls, a period highly sensitive to estrogenic stimulation.
OBJECTIVES AND METHODS: We conducted a cross-sectional analysis among 163 girls, aged 9 and 10 years, participating in the Jersey Girl Study to measure urinary mycoestrogens and their possible relationship to body size and development.
RESULTS: We found that mycoestrogens were detectable in urine in 78.5% of the girls, and that urinary levels were predominantly associated with beef and popcorn intake. Furthermore, girls with detectable urinary ZEA mycoestrogen levels tended to be shorter and less likely to have reached the onset of breast development.
CONCLUSIONS: Our findings suggest that ZEA mycoestrogens may exert anti-estrogenic effects similar to those reported for isoflavones. To our knowledge, this was the first evaluation of urinary mycoestrogens and their potential health effects in healthy girls. However, our findings need replication in larger studies with more heterogeneous populations, using a longitudinal approach.
Authors:
Elisa V Bandera; Urmila Chandran; Brian Buckley; Yong Lin; Sastry Isukapalli; Ian Marshall; Melony King; Helmut Zarbl
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-04
Journal Detail:
Title:  The Science of the total environment     Volume:  409     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-02-27     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5221-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
The Cancer Institute of New Jersey, Department of Pediatric Endocrinology, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08901, United States. elisa.bandera@umdnj.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Height
Body Weight
Breast / drug effects*,  growth & development
Cattle
Child
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Endocrine Disruptors / adverse effects*,  analysis,  urine
Environmental Exposure / adverse effects*,  analysis
Estrogens, Non-Steroidal / adverse effects*,  analysis,  urine
Female
Food Contamination / analysis
Health Surveys
Humans
Isoflavones / analysis
Mass Spectrometry
New Jersey
Puberty
Zea mays / chemistry
Zearalenone / adverse effects*,  analogs & derivatives,  analysis,  urine
Zeranol / adverse effects,  analogs & derivatives,  analysis,  urine
Grant Support
ID/Acronym/Agency:
K22 CA138563/CA/NCI NIH HHS; K22 CA138563-02/CA/NCI NIH HHS; K22CA138563/CA/NCI NIH HHS; P30 ES005022/ES/NIEHS NIH HHS; P30 ES005022-20/ES/NIEHS NIH HHS; P30ES005022/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/zearalenol; 17924-92-4/Zearalenone; 26538-44-3/Zeranol
Comments/Corrections

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