Document Detail

Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis.
MedLine Citation:
PMID:  20683619     Owner:  NLM     Status:  In-Process    
Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma MCP-1 levels compared to adult and childhood controls. The median age and SLE disease duration of patients were 14.4 and 5.5 years, respectively. LN patients had a higher median renal (p=0.01) British Isles Lupus Assessment Group (BILAG) index, with a tendency for higher total BILAG scores (p=0.2). There were significantly increased urinary MCP-1 levels in the LN patients compared to healthy controls (p<0.001) whose values were significantly higher than lupus non-nephritis children (p<0.004). Urinary MCP-1 levels correlated well with total BILAG scores (r=0.82, p=0.04). There were no differences in plasma MCP-1 levels between SLE patient groups and pediatric controls, although the levels in the childhood controls were elevated compared to those of the adult controls (p<0.04). These results provide evidence of increased urinary--but not plasma--MCP-1 levels in children with LN, which correlates well with SLE disease activity as measured by the BILAG index.
Stephen D Marks; Vanita Shah; Clarissa Pilkington; Kjell Tullus
Related Documents :
1342889 - Autoantibodies in splenectomized patients as a consequence of abdominal trauma.
18577409 - Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythe...
11204589 - Some patients with antiphospholipid syndrome express hitherto undescribed antibodies to...
1288419 - Clinical evaluation of scleroderma spectrum disorders using a points system.
17488749 - A comparison of autoimmune liver disease in juvenile and adult populations with systemi...
1971739 - Heterogeneity of laboratory test results for antiphospholipid antibodies in patients tr...
4002809 - Muzolimine in patients on chronic hemodialysis (hd) and continuous ambulatory peritonea...
9444579 - Efficacy of conservative treatment of lumbar disc herniation.
24173909 - Serum adipokine levels in rheumatoid arthritis patients and their contributions to the ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-05
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  25     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2283-8     Citation Subset:  IM    
Nephro-Urology Unit, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Similar renal outcomes in children with ADPKD diagnosed by screening or presenting with symptoms.
Next Document:  Modeled response of the West Nile virus vector Culex quinquefasciatus to changing climate using the ...